Evidence map›Paper›PMID 40740296›Full record

ReviewComputational and structural biotechnology journal2025

Integrate & balance aspects for safe and sustainable innovation: Needs analysis on SSbD categories and product development stage requirements to cover the entire life cycle.

Gustavo Martin Larrea-Gallegos, Sabine Hofer, Norbert Hofstätter, Benjamin Punz, Nico Watzek, Wibke Lölsberg, Karin Wiench, Wendel Wohlleben, Irantzu Garmendia Aguirre, Nikolakopoulos Athanassios and 8 more

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gustavo Martin Larrea-GallegosEnvironmental Sustainability and Circularity Assessment (SUSTAIN) Research Unit, Luxembourg Institute of Science and Technology, 5, avenue des Hauts-Fourneaux, Esch/Alzette L-4362, Luxembourg.
Sabine HoferDept. Biosciences & Medical Biology, Paris Lodron University of Salzburg (PLUS), Hellbrunnerstrasse 34, Salzburg 5020, Austria.
Norbert HofstätterDept. Biosciences & Medical Biology, Paris Lodron University of Salzburg (PLUS), Hellbrunnerstrasse 34, Salzburg 5020, Austria.
Benjamin PunzDept. Biosciences & Medical Biology, Paris Lodron University of Salzburg (PLUS), Hellbrunnerstrasse 34, Salzburg 5020, Austria.
Nico WatzekBASF SE, Carl-Bosch-Straße 38, Ludwigshafen am Rhein 67056, Germany.
Wibke LölsbergBASF SE, Carl-Bosch-Straße 38, Ludwigshafen am Rhein 67056, Germany.
Karin WienchBASF SE, Carl-Bosch-Straße 38, Ludwigshafen am Rhein 67056, Germany.
Wendel WohllebenBASF SE, Carl-Bosch-Straße 38, Ludwigshafen am Rhein 67056, Germany.
Irantzu Garmendia AguirreEuropean Commission, Joint Research Center (JRC), Ispra, Italy.
Nikolakopoulos AthanassiosSchool of Chemical Engineering, National Technical University of Athens (NTUA), Zografou 15780, Greece.
Haralambos SarimveisSchool of Chemical Engineering, National Technical University of Athens (NTUA), Zografou 15780, Greece.
Anna CostaIstituto di Scienza e Tecnologia dei Materiali Ceramici (CNR-ISSMC), Via Granarolo, 64, Faenza, RA 48018, Italy.
Christian SeitzAcumenIST, Rue Fétis 19, Etterbeek 1040, Belgium.
Steffi FriedrichsAcumenIST, Rue Fétis 19, Etterbeek 1040, Belgium.
Thomas E ExnerSevenpastnine GmbH, Rebacker 68, Schopfheim79650, Germany.
Roland HischierTechnology & Society Laboratory, Swiss Federal Laboratories for Materials Science and Technology (EMPA), Lerchenfeldstrasse 5, St. Gallen 9014 , Switzerland.
Antonino MarvugliaEnvironmental Sustainability and Circularity Assessment (SUSTAIN) Research Unit, Luxembourg Institute of Science and Technology, 5, avenue des Hauts-Fourneaux, Esch/Alzette L-4362, Luxembourg.
Martin HimlyDept. Biosciences & Medical Biology, Paris Lodron University of Salzburg (PLUS), Hellbrunnerstrasse 34, Salzburg 5020, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current EU Strategies aim to rapidly advance the research, development and deployment of innovative advanced materials and chemicals to make Europe the first digitally enabled circular, climate-neutral and sustainable economy. To achieve this, an underlying adaptation of the research and innovation (R&I) process to the Safety-and-Sustainability-by-Design (SSbD) framework has been proposed. This perspective article provides an overview of already existing approaches providing guidance for implementing SSbD-like procedures in R&I in several different industrial sectors to ultimately replace substances of concern (SoC). Starting from the ECHA's Assessment of Alternatives (AoA) approach we put emphasis on the scoping phase during which the requirements for replacement will be identified. The limitations for the changes possible and trade-offs acceptable for the company need to be defined, in agreement with relevant stakeholders to be further involved in AoA scoping (

Indexed as

artificial intelligencedigitalizationFAIR datagreen chemistryinnovative advanced materialslife cycle assessmentmachine learningmulti-objective optimizationresponsible research & innovationSafe & sustainable by designSSbD frameworksubstitution chemicals

Identifiers

PMID40740296
PMCPMC12309855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.