ArticleFrontiers in neuroscience2025
Association of rs440446 in the APOE intron region with multidimensional cognitive function, lipid/metabolic markers, and spontaneous neural activity in Chinese urban community-dwelling older adults.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Beyond Targeted Gene Panels: Whole-Exome Sequencing as a Strategic Platform for Precision Therapeutics in Alzheimer's Disease.Life (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: rs440446 (+ 113G/C), located in the intron of the APOE gene, has unclear effects on cognition, blood lipids, metabolic markers, and neural activity in older Chinese adults. Methods: A total of 505 older adults from communities in Qingdao were enrolled and categorized into C-allele carriers ( Results: rs440446 GG homozygotes were associated with poorer language function. This association was consistently observed in female, ≥ 60 years old, and APOE ε4 non-carrier subgroups. However, no significant relationship was found between the GG genotype and lipid or metabolic markers. In fALFF analysis, GG homozygotes exhibited decreased spontaneous neural activity in the left middle occipital gyrus (MOG.L) and right cuneus (CUN.R), while showing increased activity in the right superior temporal gyrus (STG.R) and left fusiform gyrus (FFG.L). Additionally, fALFF values in the CUN.R were positively correlated with attention, whereas fALFF values in the STG.R were negatively correlated with memory. Conclusion: rs440446 GG homozygote may be associated with alterations in language function and spontaneous neural activity among older adults.
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