Evidence map›Paper›PMID 40740252›Full record

ArticleMaterials today. Bio2025

Engineered lipid nanoparticles with synergistic dendritic cell targeting and enhanced endosomal escape for boosted mRNA cancer vaccines.

Sizhen Wang, Jianyu Zheng, Jiao Zhou, Weiwei Jiang, Zhendong Chen, Xiaoxian Wu, Beibei Guo, Yanfeng Wu, Feng Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sizhen WangNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Jianyu ZhengNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Jiao ZhouNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Weiwei JiangNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Zhendong ChenNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Xiaoxian WuNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Beibei GuoNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Yanfeng WuNational Key Laboratory of Immunity and Inflammation & Institute of Immunology, College of Basic Medical Sciences, Naval Medical University, Shanghai, 200433, China.
Feng YangNational Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid nanoparticles (LNPs) have emerged as a pivotal carriers for enhancing mRNA therapeutics, particularly in antitumor therapy. However, achieving robust antigen expression remains a major challenge due to limitations in precise targeted delivery and inefficient endosomal escape. In this study, we constructed an ambidextrous LNP to achieve robust tumor-specific antigen expression through targeted cell delivery and enhanced endosomal escape of mRNA-LNPs. To improve endosomal escape, we synthesized a novel pH-responsive PEGylated lipid designed to synergistically enhance membrane fusion effect with ionizable lipids, thereby optimizing the translation of the desired antigen. This is accomplished by promoting the early endosomal escape and endosomal recycling transport. For precise delivery of mRNA-LNPs to dendritic cells, we employed a mannose-modified PEGylated lipid that targets mannose receptors. Our results demonstrated that the combination of mannose-directed targeting and pH-mediated endosomal escape significantly enhances antigen translation and expression, leading to a vigorous immune response, as validated by both in vitro and in vivo experiments. This ambidextrous strategy advances the formulation of LNPs for precise mRNA delivery and effective antigen encoding, facilitating the development of mRNA vaccines in the field of antitumor immunology.

Indexed as

Antitumor immunologyDC-Targeting abilityEndosomal escapeLipid nanoparticlemRNA therapy

Identifiers

PMID40740252
PMCPMC12308020

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.