Evidence map›Paper›PMID 40740245›Full record

ArticleJournal of Cancer2025

Impact of PIK3CA Mutations on the Clinical Benefits of CDK 4/6 Inhibitors in HR+/HER2- Advanced Breast Cancer: An Updated Pairwise and Network Meta-Analysis.

Sheng-Fan Wang, Chian-Ying Chou, Yi-Wen Chao, Tzu-Kuan Chan, Wan-Yu Yeh, Chern-En Chiang, Chen-Huan Chen, Hsin-Chen Lee, Ling-Ming Tseng, Yuh-Lih Chang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheng-Fan WangDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Chian-Ying ChouDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Yi-Wen ChaoDepartment of Pharmacy, College of Pharmaceutical Sciences, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Li-Nong St., Beitou, Taipei 112, Taiwan.
Tzu-Kuan ChanDepartment of Pharmacy, College of Pharmaceutical Sciences, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Li-Nong St., Beitou, Taipei 112, Taiwan.
Wan-Yu YehCenter for Evidence-based Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Chern-En ChiangSchool of Medicine, College of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Beitou, Taipei 112, Taiwan.
Chen-Huan ChenDepartment of Medical Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Hsin-Chen LeeDepartment and Institute of Pharmacology, College of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Beitou, Taipei 112, Taiwan.
Ling-Ming TsengSchool of Medicine, College of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Beitou, Taipei 112, Taiwan.
Yuh-Lih ChangDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Hao-Min ChengDepartment of Medical Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.
Chun-Yu LiuDivision of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou, Taipei 112, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

advanced breast cancercyclin-dependent kinase 4/6hormone receptor-positivehuman epidermal growth factor receptor-2 negativePIK3CA

Identifiers

PMID40740245
PMCPMC12305603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.