ArticleJournal of Cancer2025
Investigation of CBX4 Polymorphisms and Their Association with Clinicopathological Features in Asian Patients with Oral Squamous Cell Carcinoma.
Article in Journal of Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Head and neck squamous cell carcinomas (HNSCCs) are derived from the mucosal epithelium in the oral cavity, pharynx and larynx, and are predominantly linked to behavioral risk factors such as tobacco use and excessive alcohol consumption. In Taiwan, oral squamous cell carcinoma (OSCC) is one of the most prevalent subtypes of HNSCC and ranks as the fifth leading cause of cancer-related mortality in the country. The Chromobox (CBX) gene family encodes core subunits of the canonical Polycomb Repressive Complex 1 (cPRC1), a key epigenetic regulator mediating chromatin compaction and transcriptional silencing through histone modification. Dysregulation of CBX gene expression, whether at the transcriptional or post-transcriptional level, has been increasingly linked to tumorigenesis, metastasis, and cancer recurrence in a variety of malignancies. In particular, CBX4 has been implicated in the progression of gastric cancer, with growing evidence suggesting its broader role in cancer development. From the TCGA database, we found that levels of
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