ArticleACS applied nano materials2024
The Predictive Synthesis of Monodisperse and Biocompatible Gold Nanoparticles.
Article in ACS applied nano materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Are Silver and Gold Nanoparticles Obtained by 'Green' Synthesis Biocompatible?Nanomaterials (Basel, Switzerland) · 2026Review
- Label-Free and High-Throughput Quantification of Nanoparticle-Cell Interactions at the Single-Cell Level with Flow Cytometry.Analytical chemistry · 2026Article
- Promoting Self-Efficacy of Biomedical Engineering Undergraduate Students Using a Deliberately Designed Nanomedicine Workshop Series.Biomedical engineering education · 2026Article
- Axially Swept Light-Sheet Microscopy using scattering and fluorescence contrast mechanisms.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Rational Synthesis of Uniform Au Nanospheres under One-Shot Injection: From Mechanistic Understanding to Experimental Control.Precision chemistry · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The predictive bottom-up synthesis of monodisperse and biocompatible gold nanoparticles using seed-mediated growth procedures is limited by a lack of mathematical models relating reaction components to the final nanoparticle diameter. In this study, we used unique quantitative analytical methods at the single-nanoparticle level to identify the mathematical relationship between the moles of precursor ionic gold and the moles of nanoparticle seeds to synthesize monodisperse gold nanoparticles within ~5% of the target diameter in the ~10 to 120 nm size range. We investigated two commonly used gold nanoparticle syntheses, i.e., the formation of (i) citrate-coated, and (ii) cetyltrimethylammonium chloride (CTAC)-coated gold nanoparticles. Additionally, we developed a surface engineering approach using a physical replacement method that replaces cytotoxic CTAC with biocompatible citrate moieties. We confirmed the successful surface removal of CTAC using several analytical methods and demonstrated biocompatibility with cell viability tests. Our study provides tools and methods by which monodisperse and biocompatible gold nanoparticles can be predictably synthesized for potential downstream biomedical applications.
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Registered trials
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