Evidence map›Paper›PMID 40740133›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Neutrophil Integrin α9 Impairs Efferocytosis and Worsens Long-Term Recovery After Subarachnoid Hemorrhage.

Harpreet Kaur, Nilesh Pandey, Lakshmi Chandaluri, Nirvana Shaaban, Dhananjay Kumar, Rajan Pandit, Alexa Martinez, Sumit Kumar Anand, Sandeep Das, Sumati Rohilla and 13 more

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In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Harpreet KaurDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0009-0005-2879-0205
Nilesh PandeyDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0003-2937-3268
Lakshmi ChandaluriDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.
Nirvana ShaabanDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.
Dhananjay KumarDepartment of Molecular and Cellular Physiology (D.K., R.P., A.Y.), Louisiana State University Health Sciences Center-Shreveport.
Rajan PanditDepartment of Molecular and Cellular Physiology (D.K., R.P., A.Y.), Louisiana State University Health Sciences Center-Shreveport.
Alexa MartinezDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.
Sumit Kumar AnandDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0003-3719-0744
Sandeep DasDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.
Sumati RohillaDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-0860-0188
Fabio AriasDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-9906-6450
Erika ReeceDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Shreveport, LA (E.R., K.S.M., X.-H.L.).ORCID 0000-0003-2295-1889
Ravinder Reddy GaddamDepartment of Internal Medicine (R.R.G., A.V.), University of Iowa.ORCID 0000-0003-1062-5082
Kevin S MurnaneDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Shreveport, LA (E.R., K.S.M., X.-H.L.).ORCID 0000-0002-8143-0541
Ajit VikramDepartment of Internal Medicine (R.R.G., A.V.), University of Iowa.ORCID 0000-0003-3724-3842
Rajesh MohandasSection of Nephrology and Hypertension, Louisiana State University Health Science Center, New Orleans, LA (R.M.).ORCID 0000-0002-4430-8678
Xiaolu ZhangBioinformatics and Modeling Core, Center for Applied Immunology and Pathological Processes, Department of Microbiology and Immunology (X.Z.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0001-5595-7270
Mohammad Alfrad Nobel Bhuiyanand Department of Medicine (M.A.N.B.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-6011-2624
Xiao-Hong LuDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Shreveport, LA (E.R., K.S.M., X.-H.L.).ORCID 0000-0002-2363-1708
A Wayne OrrDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-2377-213X
Oren RomDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-9272-086X
Arif YurdagulDepartment of Molecular and Cellular Physiology (D.K., R.P., A.Y.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0002-7613-6313
Nirav DhaneshaDepartment of Pathology and Translational Pathobiology (H.K., N.P., L.C., N.S., A.M., S.K.A., S.D., S.R., F.A., A.W.O., O.R., N.D.), Louisiana State University Health Sciences Center-Shreveport.ORCID 0000-0001-9268-4363

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Gopi K Kolluru · 2018 to 2026
$23.6M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
Nck Adaptor Proteins in Atherogenic Endothelial ActivationR01HL133497 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2016 to 2024
$3.8M
Dysregulations in Polyamine Metabolism During AtherosclerosisR01HL167758 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Arif Yurdagul · 2023 to 2026
$2.2M
Mechanisms for Deep Vein Thrombosis following StrokeR01HL158546 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Nirav Dhanesha · 2022 to 2026
$2.2M
EphA2 regulation of atherosclerotic smooth muscle phenotypeR01HL173972 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Anthony Wayne Orr · 2024 to 2026
$2.1M
Lipidated Amino Acids in Cardiometabolic DiseasesR01DK134011 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Oren Rom · 2022 to 2026
$2.1M
EphA2 signaling in atherosclerotic fibroproliferative remodelingR01HL141155 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2019 to 2022
$1.8M
Dysregulated Oxalate Metabolism in Cardiometabolic DiseasesR01DK136685 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Oren Rom · 2023 to 2026
$1.7M
Glycopeptide vancomycin reshapes gut microbiota to mediate cardioprotective effects via microRNA-204R01HL167773 · NHLBI · UNIVERSITY OF IOWA · PI Ajit Vikram · 2024 to 2026
$1.5M
Mechanisms of glycine-based therapy for atherosclerosisR00HL150233 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ROM, OREN SHALOM · 2021 to 2023
$747k
Processing of Apoptotic Cell-Derived Cargo by Macrophages Continues Efferocytosis and Drives Atherosclerosis RegressionR00HL145131 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI YURDAGUL, ARIF · 2021 to 2023
$747k
NHLBI NIH HHS K99 HL145131NHLBI NIH HHS K99 HL150233NHLBI NIH HHS R00 HL145131NHLBI NIH HHS R00 HL150233NHLBI NIH HHS R01 HL133497NHLBI NIH HHS R01 HL141155NHLBI NIH HHS R01 HL158546NHLBI NIH HHS R01 HL167758NHLBI NIH HHS R01 HL167773NHLBI NIH HHS R01 HL173972NIDDK NIH HHS R01 DK134011NIDDK NIH HHS R01 DK136685NIGMS NIH HHS P20 GM121307NIGMS NIH HHS P20 GM134974
6 · The paper itself

Abstract

backgroundNeutrophil infiltration exacerbates brain injury after subarachnoid hemorrhage (SAH). Integrin α9, expressed on neutrophils, facilitates their adhesion and transendothelial migration, leading to aggravated inflammatory responses and neuronal apoptosis. Insufficient clearance of apoptotic neurons by microglia and infiltrating blood-derived macrophages (defective efferocytosis) contributes to persistent inflammation and poor SAH recovery. This study investigated the role of neutrophil integrin α9 in neuronal apoptosis, microglia/macrophage efferocytosis, and SAH outcomes.

methodsNeutrophil-specific

resultsMice subjected to SAH exhibited increased integrin α9 levels on infiltrated neutrophils compared with sham surgery controls. Neutrophil-specific

conclusionsOur study revealed a novel role for neutrophil integrin α9 in sensorimotor function and cognitive recovery after SAH, suggesting it as a potential therapeutic target for SAH.

Indexed as

Integrin alpha ChainsNeuronsNeutrophilsPhagocytosisSubarachnoid HemorrhageAnimalsApoptosisCells, CulturedDisease Models, AnimalEfferocytosisMacrophagesMaleMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, Knockoutintegrin alpha9Integrin alpha ChainsMatrix Metalloproteinase 9Mmp9 protein, mouseefferocytosisintegrinsmicroglianeutrophilssubarachnoid hemorrhage

Identifiers

PMID40740133
PMCPMC12333561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.