Evidence map›Paper›PMID 40740058›Full record

ReviewTechnology in cancer research & treatment

Prognostic Biomarkers for Papillary Thyroid Cancer: Reducing Overtreatment, Improving Clinical Efficiency, and Enhancing Patient Experience.

Oliver F Bathe, Cynthia Stretch

Abstract readReview
In one paragraph

Review in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Oliver F BatheArnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Cynthia StretchArnie Charbonneau Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-5152-2728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary thyroid cancer (PTC), the most prevalent form of thyroid malignancy, is generally indolent but poses a recurrence risk of 10%-15%, leading to a clinical paradox: the need to mitigate recurrence while avoiding overtreatment. Current prognostic frameworks, reliant on anatomical and histopathological factors, often result in inefficient treatment pathways, unnecessary surgical interventions, and increased patient burden. The advent of molecular diagnostics presents a paradigm shift in risk stratification. Implementing preoperative molecular tests could transform PTC management by enabling tailored therapeutic strategies, reducing the need for completion thyroidectomies, optimizing the selection of patients for active surveillance, and refining the use of adjuvant therapies such as radioactive iodine. While genomic alterations such as

Indexed as

Biomarkers, TumorThyroid Cancer, PapillaryThyroid NeoplasmsGene Expression ProfilingHumansNeoplasm Recurrence, LocalOvertreatmentPrognosisBiomarkers, Tumorbiomarkergenomeprognosisthyroid cancertranscriptome

Identifiers

PMID40740058
PMCPMC12317244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.