Evidence map›Paper›PMID 40739903›Full record

ArticleJournal of veterinary internal medicine

Trigeminal Nerve Asymmetry in Horses With Idiopathic Trigeminal-Mediated Headshaking: A Retrospective Case-Control Magnetic Resonance Imaging Study.

Frederik Heun, Julien Delarocque, Karsten Feige, Maren Hellige

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In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frederik HeunClinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.ORCID https://orcid.org/0000-0001-6928-3772
Julien DelarocqueClinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.ORCID https://orcid.org/0000-0002-4598-3499
Karsten FeigeClinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Maren HelligeClinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNerve atrophy results in trigeminal nerve (TN) asymmetry detectable by magnetic resonance imaging (MRI) in humans, but similar studies have not been performed in horses with idiopathic trigeminal-mediated headshaking (ITMHS). HYPOTHESIS: Horses with ITMHS show greater MRI-detected trigeminal-nerve asymmetry than controls. ANIMALS: A total of 20 adult horses with ITMHS and six unaffected control horses.

methodsRetrospective case-control study of the TN cross-sectional area (TNCSA) based on 3-Tesla MRI scans of the equine brain. TNCSA and its side-to-side differences at four defined measurement points were compared within the two study groups using a linear mixed model. Intraclass correlation coefficient analysis was used to evaluate intra-rater repeatability. The primary outcome was side-to-side TNCSA asymmetry, minimizing confounding effects such as body size.

resultsSignificantly greater TNCSA side-to-side differences (asymmetry of TN) were detected in horses with ITMHS (F CONCLUSIONS AND CLINICAL IMPORTANCE: The asymmetry of the TNCSA in horses with ITMHS indicates unilateral or asymmetric disease of the TN. The present study highlights the value of MRI examinations in ITMHS and could pave the way for targeted therapeutic approaches.

Indexed as

Horse DiseasesTrigeminal NerveTrigeminal Nerve DiseasesAnimalsCase-Control StudiesFemaleHorsesMagnetic Resonance ImagingMaleRetrospective Studiesbrainequinemagnetic resonance imagingneuralgianeuropathy

Identifiers

PMID40739903
PMCPMC12311309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.