ArticleCNS neuroscience & therapeutics2025
Neural Plasticity Induced by Working Memory Training: Insights From Cortical Microstructure and Transcriptional Profiles.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Longitudinal surface-based morphometry reveals potential MRI biomarkers correlated with multidimensional brain health measures.Brain imaging and behavior · 2026Article
- Longitudinal Surface-Based Morphometry Reveals Potential MRI Biomarkers Correlated with Multidimensional Brain Health Measures.Research square · 2025Article
- Neural Plasticity Induced by Working Memory Training: Insights From Cortical Microstructure and Transcriptional Profiles.CNS neuroscience & therapeutics · 2025Article
- Investigation of cerebral cortical morphological similarity and network topological abnormalities in hepatic encephalopathy utilizing a morphometric inverse divergence network framework.Frontiers in neurologyArticle
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Authors and funding
11 authors.
Funding
Abstract
aimsTo investigate the effects of an 8-week standardized computerized working memory training (WMT) program on cortical microstructure, morphometric similarity network (MSN) changes, and associated genetic factors in healthy adults.
methodsA total of 76 participants were divided into WMT and control groups. Cortical morphological measurements, including cortical thickness (CT) and fractional dimensions (FD), were measured. MSN changes based on CT and FD measures were analyzed. Additionally, partial least squares (PLS) analysis was conducted to investigate the relationship between critical microstructural alterations and gene transcript expression levels.
resultsThe WMT group exhibited reduced response times for updating, switching functions, and phonological loop tasks. The cortical morphological measurements revealed increases in CT in several right frontal regions, as well as FD in the frontopolar and middle frontal areas after WMT compared to baseline. Furthermore, significant decreases in MSN based on CT measures were found in specific occipital and intraparietal sulci. Similarly, the MSN of FD showed notable decreases in eigenvector and degree centrality in the left frontomarginal cortex and right middle temporal gyrus. PLS analysis revealed strong links between microstructural changes and gene expression, with PLS+ genes enriched in synaptic transmission, neural regulation, and energy metabolism, while PLS- genes were associated with intracellular transport, protein modification, and stress responses.
conclusionThe findings highlight the subtle influences of WMT on brain structure and underlying biological processes, providing insights into its role in neural plasticity and suggesting potential genetic contributions to these structural changes.
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