ArticleActa paediatrica (Oslo, Norway : 1992)2025
Parity Influences the Immune Profile of Human Milk via Increased T Lymphocyte Content.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life.International breastfeeding journal · 2025Article
- Osteocalcin in human breast milk over the course of lactation.Frontiers in endocrinology · 2025Observational
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
aimBreast milk contains immune cells, but the factors influencing their composition are not fully understood. The role of maternal reproductive history in shaping this composition has largely been overlooked. The aim of this study was to evaluate the content of leukocytes, stem cells, and lactocytes in the milk of primiparous mothers compared to multiparous mothers.
methodsForty-nine breastfeeding mothers were enrolled in the study: primiparous and multiparous women. Human milk was collected from each participant to assess the content ofthe leukocyte (CD45+), including B lymphocytes (CD19+), NK lymphocytes (CD 16/56+), and T lymphocytes (CD3+), with their subpopulations (CD4+ helper lymphocytes and CD8+ cytotoxic lymphocytes). The percentage of haematopoietic stem cells (CD45-CD105+34+326-), mesenchymal stem cells (CD45-CD105+73+44+) and lactocytes (CD45-CD105+326+) was also determined.
resultsThe percentage of lactocytes with the CD326+73- phenotype was significantly higher in multiparous women (95% vs. 89%; p = 0.016), while the percentage of lactocytes with the 326+73+ phenotype was significantly higher in primiparous women (3% vs. 0.7%; p = 0.035). A statistically significantly lower percentage of T helper and T cytotoxic lymphocytes was observed in the first-time mothers (20% vs. 30% respectively; p = 0.049 and 14% vs. 24% respectively; p = 0.006).
conclusionsParity was associated with differences in breast milk composition.
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