ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Adverse childhood experiences influence markers of neurodegeneration risk in older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Adverse childhood experiences, early menopause, cognition, and dementia in older adults in the United States.Communications health · 2026Article
- From Early Adversity to Neurodegeneration: Stress Biomarkers as Predictive Signals for Lifespan Brain Health.International journal of molecular sciences · 2025Review
- Adverse childhood experiences influence markers of neurodegeneration risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
introductionAdverse childhood experiences (ACEs) disrupt brain development and increase vulnerability to Alzheimer's disease and related dementias (ADRD). We explored how ACEs impact neuroimaging, plasma biomarkers, and cognition in older adults.
methodsData from 214 participants aged ≥ 55 years were analyzed using linear and logistic regression, adjusting for demographic covariates.
resultsFinancial need associated negatively with Montreal Cognitive Assessment scores (β = -0.10, p = 0.011). Lower mean diffusivity across white matter tracts associated with parental violence (β = -0.01, p = 0.03). Lower glial fibrillary acidic protein associated with parental intimidation (β = -0.07, p = 0.01) and parental violence (β = -0.18, p = 0.006). Family problems and separation (β = -0.16, p = 0.003), financial need (β = -0.1, p = 0.04), and parental intimidation (β = -0.05, p = 0.01) inversely associated with neurofilament light chain. DISCUSSION: Findings challenge the notion that ACEs uniformly accelerate neurodegeneration. Longitudinal studies are needed to determine whether these results reflect resilience, survivorship, or cohort-specific factors influencing ADRD risk. HIGHLIGHTS: Adverse childhood experiences (ACEs) may elicit compensatory neural responses in aging. Financial need was associated with lower global cognition (Montreal Cognitive Assessment scores). Some ACEs (e.g., financial need, parental intimidation) linked to lower plasma neurofilament light chain. Parental violence linked to lower glial fibrillary acidic protein and mean diffusivity values, implying intact white mattery integrity.
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