ArticleInternational journal of retina and vitreous2025
Retinal parameter analysis and diagnostic potentail exploration in familial exudative vitreoretinopathy using ultra-widefield fundus photography.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundFamilial Exudative Vitreoretinopathy (FEVR) is a monogenic disorder causing retinal vascular impairment, often underdiagnosed due to its variable presentation and reliance on invasive methods like fundus fluorescein angiography (FFA). Through the utilization of non-invasive ultra-widefield fundus photography (UWFFP), this research explored both the diagnostic potential of integrated retinal parameters for the detection of FEVR, and their characteristic changes during the early stage progression.
methodsRetinal parameters were systematically extracted and quantified from UWFFP of 114 FEVR patients and 114 matched controls using the EVision AI cloud platform. Comparative statistical analyses were performed to identify significant intergroup differences between FEVR and control cohorts, and assess intra-group variations among FEVR subgroups. Based on parameters that showed significant differences between the FEVR group and the control group and had an impact on the FEVR group, a diagnostic model was constructed. Receiver operating characteristic (ROC) curves were plotted to determine the diagnostic potential of these parameters. In addition, subgroup analysis within the FEVR group was conducted to clarify the relationship between retinal parameters and disease staging.
resultsSignificant differences were observed in 25 retinal parameters between the FEVR group and the control group, with the horizontal cup-to-disc ratio, vertical cup-to-disc ratio, optic disc-to-macula distance, and vascular density demonstrating potential diagnostic efficacy. Subgroup analysis within the FEVR group revealed that as the disease stage advanced and severity increased, the optic disc and cup diameters decreased, the optic disc-to-macula distance increased, and the vascular fractal dimension and vascular density parameters declined.
conclusionsUWFFP and automated retinal parameter analysis offer promising tools for early FEVR diagnosis, with specific structural and vascular markers providing diagnostic potential. Further large-scale studies are needed to validate these findings and refine diagnostic models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.