Evidence map›Paper›PMID 40739587›Full record

ArticleMilitary Medical Research2025

Ultrasound initiated tumor catalytic PANoptosis by mesoporous piezoelectric nanocatalysts.

Xuan-Shou Xu, Wei-Wei Ren, Heng Zhang, Dong-Liang Huo, Qi Lyu, Mei-Xiao Zhan, Hui-Xiong Xu, Li-Ying Wang, Min-Feng Huo, Jian-Lin Shi

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Article in Military Medical Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Targeting the non-coding RNA-PANoptosis axis: a novel frontier in disease diagnosis and therapy.Apoptosis : an international journal on programmed cell death · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuan-Shou Xu *Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China.
Wei-Wei Ren *Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China.
Heng Zhang *Department of Ultrasound, Zhuhai People's Hospital (the Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, Guangdong, China.
Dong-Liang HuoDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China.
Qi LyuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, 200032, China.
Mei-Xiao ZhanDepartment of Ultrasound, Zhuhai People's Hospital (the Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, Guangdong, China.
Hui-Xiong XuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, 200032, China. xu.huixiong@zs-hospital.sh.cn.
Li-Ying WangDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China. ly_wang@tongji.edu.cn.
Min-Feng HuoDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China. mfhuo@tongji.edu.cn.ORCID 0000-0001-5717-1845
Jian-Lin ShiDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering and Nano Science School of Medicine, Tongji University School of Medicine, Shanghai, 200072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPANoptosis has been identified as a robust inflammatory cell death pathway triggered upon host defense against invaded pathogens such as bacteria and viruses, however, pathogen-free tumor PANoptosis has not been achieved yet. Reactive oxygen and nitrogen species capable of inducing robust and diverse cell death pathways such as pyroptosis, apoptosis, and necroptosis are supposed to be the potential triggers for tumor PANoptosis by ultrasound (US)-controlled sono-piezodynamic therapy.

methodsS-nitrosothiols (SNO)-zinc peroxide (ZnO

resultsA "boiling-bubbling" strategy is developed to endow the piezoelectric BTO nanocatalysts, with mesoporous architecture, which enables the encapsulation of the immune-agonist CDN (9.4 wt%) to initiate innate immunity of the host. Then, SNO-functionalized ZnO

conclusionThe present work presents the mesostructure design of piezocatalytic nanomaterials and the crosstalk between oxidative stress and antitumor immunity within the tumor, facilitating promising tumor PANoptosis by nanocatalytic oxidation with high effectiveness and biocompatibility.

Indexed as

Cell DeathMelanoma, ExperimentalNanoparticlesUltrasonic TherapyAnimalsCatalysisCell Line, TumorMiceMice, Inbred C57BLSpectroscopy, Fourier Transform InfraredX-Ray DiffractionImmunotherapyMesopore engineeringPiezoelectric nanocatalystSonodynamic therapyTumor PANoptosis

Identifiers

PMID40739587
PMCPMC12312345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.