Evidence map›Paper›PMID 40739558›Full record

ArticleBMC health services research2025

A cost minimization analysis of the implementation of the international lung screening trial in Catalonia (Spain).

Antoni Rosell, Sonia Baeza, Rocío Mouriño, Maria Saigí, Marta Munné, Pedro López de Castro, Jordi Bechini, Oriol Estrada, Jordi Ara, Laura Ricou and 1 more

Abstract read
In one paragraph

Article in BMC health services research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antoni RosellBarcelona Respiratory Network (BRN), Thorax Institute, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona (UAB), Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain.
Sonia BaezaGermans Trias i Pujol University Hospital, Department of Medicine, Autonomous University of Barcelona (UAB), Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain.
Rocío MouriñoCentre for Research in Health Economics (CRES), Pompeu Fabra University, Barcelona, Spain.
Maria SaigíCatalan Institute of Oncology, Badalona, Barcelona, Spain.
Marta MunnéCatalan Institute of Oncology, Badalona, Barcelona, Spain.
Pedro López de CastroThoracic Surgery Service, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain.
Jordi BechiniBarcelona Respiratory Network (BRN), Thorax Institute, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona (UAB), Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain.
Oriol EstradaDirectorate of Healthcare Strategy, Northern Metropolitan Territorial Management, Catalan Institute of Health, Barcelona, Spain.
Jordi AraNorthern Metropolitan Territorial Management, Catalan Institute of Health, Barcelona, Spain.
Laura RicouCentre for Research in Health Economics (CRES), Pompeu Fabra University, Barcelona, Spain.
Francesc López-SeguíCentre for Research in Health Economics (CRES), Pompeu Fabra University, Barcelona, Spain. francesc.lopezs@upf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNLST and NELSON trial showed that lung cancer mortality can be reduced by 20-24% using low-dose computed tomography screening, due to an increase in early-stage diagnoses. RESEARCH QUESTION: How much lung cancer-related direct costs may be reduced using low-dose computed tomography screening based on the ILST-protocol in a public healthcare system?

methodsCost analysis of lung cancer screening vs. usual care in the framework of the retail price of the Catalan public healthcare system. The lung cancer screening group included costs of screening (ILST-protocol), treatment cost according to weighted average distribution of TNM staging in the NLST and NELSON trials, lung cancer detection rate and smoking-cessation intervention. The usual care group included treatment costs based on distribution of TNM staging registered in the Spanish index hospital.

resultsIn the usual care group, treatment costs were €91,959. In 5-year of lung cancer screening program, the average expected costs per subject were €1,342 (range €1,054 - 1,832) for screening and €32,431 for treatment, with an expected reduction of €952 based on an average cancer detection rate of 1.6%. The decrease in cost resulting from the stage shift offsets 70.6% of the costs of the screening program.

conclusionsThe decrease in direct costs associated with lung cancer treatment due to a stage shift resulting from LCS of high-risk populations compensates for a substantial part of the LCS program costs.

trial registrationRetrospectively registered.

Indexed as

Early Detection of CancerLung NeoplasmsMass ScreeningTomography, X-Ray ComputedAgedCosts and Cost AnalysisFemaleHumansMaleMiddle AgedNeoplasm StagingSpainCost analysisEarly stageHealth economicsLung cancerScreening program

Identifiers

PMID40739558
PMCPMC12308991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.