Evidence map›Paper›PMID 40739478›Full record

ArticleBMC anesthesiology2025

Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum.

Sa Wang, Xin-Xin Zhao, Dan Tang, Shi-An Li, Tian-Qi Li, Bing-Xue Peng, Yi-Hao Wang, Sai-Hong Xu, Po Gao, Xue Xue and 3 more

Abstract read
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In one paragraph

Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Sa Wang *Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Xin-Xin Zhao *Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Dan Tang *Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Shi-An LiDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Tian-Qi LiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300353, China.
Bing-Xue PengDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Yi-Hao WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Sai-Hong XuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Po GaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Xue XueState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300353, China.
Ying-Fu JiaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. yingfu.jiao@sjtu.edu.cn.
Yan ZhouDepartment of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. zhouyan@renji.com.
Wei-Feng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. ywf808@yeah.net.

Funding

Clinical Research Project of Health Industry of Shanghai Health Committee 20194Y0087Innovative Research Team of High-level Local University in Shanghai SHSMU-ZDCX20211102National Natural Science Foundation of China 32030043National Natural Science Foundation of China 82270916National Natural Science Foundation of China 82302147National Natural Science Foundation of China 82371478Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation 20DZ2254200Shanghai Science and Technology Commission Medical Municipal Key Clinical Special Fund 21Y11906000State Key Laboratory of Medicinal Chemical Biology 2022011
6 · The paper itself

Abstract

backgroundPrecise anesthesia is essential to ensure perioperative safety in patients with hepatic encephalopathy (HE) due to severe liver injuries. Hyperammonemia has been implicated as a possible trigger for HE. However, anesthetic sensitivity in HE and the role of hyperammonemia, in the context of anesthetic sensitivity of HE both remain uncertain.

methodsWe injected male Sprague Dawley rats with thioacetamide (TAA) to induce acute HE. The time to lose and recover the righting reflex induced by either the inhalation anesthetic isoflurane or the intraperitoneal anesthetic propofol, as well as the 50% effective dosage (ED

resultsRats with TAA-induced acute HE took significantly reduced latency to lose the righting reflex and significantly prolonged recovery time under both isoflurane and propofol anesthesia. Additionally, the rats with TAA-induced acute HE displayed a reduction in the ED

conclusionOur results indicate that hyperammonemia increases sensitivity to anesthetic drugs in HE. Neuroimaging evidence suggests the brain areas represents by the cerebellum may constitute to hyperammonemia-associated anesthetic hypersensitivity.

Indexed as

CerebellumHepatic EncephalopathyHyperammonemiaAnesthetics, InhalationAnesthetics, IntravenousAnimalsDisease Models, AnimalIsofluraneMagnetic Resonance ImagingMalePropofolRatsRats, Sprague-DawleyReflex, RightingThioacetamideAnesthetics, InhalationAnesthetics, IntravenousIsofluranePropofolThioacetamideFunctional magnetic resonance imaging (fMRI)Hepatic encephalopathyHyperammonemia

Identifiers

PMID40739478
PMCPMC12308986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.