Evidence map›Paper›PMID 40739457›Full record

ArticleAnalytical and bioanalytical chemistry2025

Real-time monitoring of cell membrane viscosity in a 3D hydrogel cultivation microenvironment using BODIPY-based fluorescent probe.

Junli Shi, Hui Chong, Xiaofei Yang, Guangjie Zhong, Shengnan Wu, Zehao Gu, Qi Tao, Dong-An Wang, Huaiguo Xue, Yi Yang and 1 more

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junli ShiSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Hui ChongSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China. chonghui@yzu.edu.cn.ORCID http://orcid.org/0000-0002-5847-3789
Xiaofei YangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Guangjie ZhongSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Shengnan WuSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Zehao GuSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Qi TaoSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Dong-An WangDepartment of Biomedical Engineering, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR.
Huaiguo XueSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Yi YangCenter Laboratory, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, People's Republic of China. yiyang187@foxmail.com.
Hang YaoSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225009, People's Republic of China. yaohang@yzu.edu.cn.

Funding

National Natural Science Foundation of China NSFC51973180Yantai Science and Technology Plan Project 2022MSGY072Young scientists lifting project of Jiangsu Province, China TJ-2022-072
6 · The paper itself

Abstract

This study reports a viscosity-responsive fluorescent probe, BODIPY-C, designed to measure viscosity in a 3D live-cell hydrogel microenvironment using a fluorescence lifetime-based method. This method enables real-time monitoring of cell membrane viscosity changes through the fluorescent lifetime signals of the probe. Functionally, the BODIPY-C exhibits microviscosity sensitivity; the non-toxic probe enables long-term tracking with high sensitivity (R

Indexed as

Boron CompoundsCell MembraneFluorescent DyesHydrogelsHumansViscosity4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent DyesHydrogels3D hydrogelBODIPY fluorescent probesCell membrane viscosityFluorescence lifetime imagingLive microenvironment

Identifiers

PMID40739457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.