Evidence map›Paper›PMID 40739382›Full record

ArticleBreast cancer research and treatment2025

Impact of timing and breastfeeding on postpartum breast cancer diagnostic patterns and outcomes.

Daniella Klebaner, Natalie Park, Kimberly Stone, Fauzia Riaz, Susan Crowe, Melinda Telli, Carol Marquez, Kathleen Horst

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Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Daniella KlebanerDepartment of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA.
Natalie ParkDepartment of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA.
Kimberly StoneDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Fauzia RiazDivision of Medical Oncology, Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Susan CroweDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.
Melinda TelliDivision of Medical Oncology, Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Carol MarquezDepartment of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA.
Kathleen HorstDepartment of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA. kateh@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostpartum breast cancers (PPBC) have a worse prognosis than other breast cancers, but the impact of timing postpartum (PP) and concurrent breastfeeding (BF) on diagnostic patterns and outcomes remains unclear.

methodsWe analyzed 161 PPBC patients diagnosed from 2002 to 2014, hypothesizing that diagnosis < 2 years PP (vs 2-5 years) and concurrent BF (vs not BF) at diagnosis would be associated with delayed diagnosis. We compared 2-year PP patients (N = 60) and 2-5 year PP patients (N = 101), and subsequently, patients who were (n = 36) and were not (n = 24) BF at diagnosis among the 2-year PP group with respect to clinicopathologic characteristics, breastfeeding details, diagnostic patterns, and disease outcomes. Differences were evaluated using chi-square and Mann-Whitney tests. Kaplan-Meier analysis assessed overall survival (OS) and distant disease-free survival (DDFS).

resultsMedian follow-up was 54 months. Patients in the 2-year PP group were more likely to be BF at diagnosis (60% vs 7%, p < 0.001), and have their symptoms attributed to lactational change (37 vs 9%, p < 0.001). They were also diagnosed at a higher stage (43 vs 24% Stage III/IV, p = 0.01), had worse 5-year OS (79% vs 97%, p < 0.001), and DDFS (74% vs 93%, p = 0.003) compared to 2-5 year PP patients. Among 2-year PP patients, patients BF at diagnosis were more likely to be diagnosed with mastitis preceding diagnosis (31% vs 4%, p = 0.03), more often had their symptoms attributed to lactational change (58% vs 4%), trended toward higher stage at diagnosis (53 vs 29% Stage III/IV, p = 0.1), had significantly worse 5-year DDFS (62% vs 91%, p = 0.032), and trended toward worse OS (74% vs 86%, p = 0.08) compared to those not BF.

conclusionsOur findings suggest that early PPBC and BF at diagnosis are associated with diagnostic delay and higher stage at diagnosis, which may have implications for prognosis.

Indexed as

Breast FeedingBreast NeoplasmsPostpartum PeriodAdultDelayed DiagnosisFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasm StagingPrognosisTime FactorsBreast neoplasmsDelayed diagnosisLactationPostpartum period

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PMID40739382

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