ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Prognostic significance of nutritional and inflammatory markers in locoregional advanced laryngeal cancer undergoing total laryngectomy.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdvanced-stage laryngeal squamous cell carcinoma (LSCC) carries a poorprognosis despite advances in surgical and adjuvant therapies. Identifying reliable prognostic markers remains critical to improving risk stratification and tailoring treatment strategies. This study evaluated the prognostic significance of inflammatory and nutritional markers, notably the Prognostic Nutritional Index (PNI) and modified Glasgow Prognostic Score (mGPS), alongside conventional pathological parameters in patients undergoing total laryngectomy.
methodsA retrospective cohort study was conducted on 111 patients with locoregional advanced LSCC treated with primary total laryngectomy between 2013 and 2020. Clinical, histopathological, and laboratory variables were analyzed. Survival outcomes were assessed using Kaplan-Meier analysis and log-rank tests. Multivariate prognostic factors were identified through Cox proportional hazards modeling.
resultsPNI < 45 was significantly associated with increased mortality (p = 0.001) and inferior mean survival (62 months vs. 98 months for PNI ≥ 45). In multivariate analysis, PNI < 45 (HR = 0.375; p < 0.001) and lymphovascular invasion (HR = 0.372; p = 0.012) emerged as independent predictors of overall survival. While nodal metastasis correlated with poor survival in univariate analysis, it did not retain significance in the multivariate model. Traditional inflammatory markers (mGPS, NLR, PLR) did not demonstrate prognostic relevance. Furthermore, PNI < 45 was associated with an increased risk of pharyngocutaneous fistula formation (p = 0.007), although neither fistula presence nor postoperative complications correlated with disease recurrence or survival.
conclusionsPNI and lymphovascular invasion are robust independent predictors of survival in patients with advanced LSCC undergoing total laryngectomy. Unlike mGPS, NLR, or PLR, PNI offers a simple, cost-effective prognostic tool that captures nutritional and immunological status. Integrating PNI into clinical practice may enhance individualized risk stratification, and prospective trials are warranted to explore whether preoperative nutritional optimization can improve outcomes in this high-risk population.
Indexed as
Identifiers
40739370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.