SynthesisJournal of neurology2025
Clinical outcomes after switching from fingolimod to B-cell-depleting therapies in multiple sclerosis: systematic review and meta-analysis.
Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Art of Sequencing Disease-Modifying Therapies in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026Review
- Long-Term Clinical and Psychological Efficacy and Safety of Ocrelizumab in People With Multiple Sclerosis: A Real-World Longitudinal Study.Health science reports · 2026Article
- Switching high efficacy therapies in Multiple Sclerosis: Does real world experience support such a strategy?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system, predominantly presenting as relapsing-remitting MS. Fingolimod decreases relapse rates by lymphocyte sequestration, yet persistent activity often requires switching to B cell-depleting therapies (BCDTs) such as ocrelizumab (OCR) or rituximab (RTX). Data on outcomes after this switch remain limited.
methodsWe searched MEDLINE, Embase, and Cochrane Library databases. Single-arm rates were pooled via weighted meta-analysis; continuous outcomes by mean differences (MD), both with 95% confidence interval (C.I.). Significance was set at P < 0.05, and heterogeneity by I
resultsEleven retrospective cohort studies (n = 1084) of MS patients switching from fingolimod to BCDTs were included in this meta-analysis. A high relapse-free proportion after switching to BCDTs (90%; 95%C.I.: 86-94%; I
conclusionMS patients who switched from fingolimod to OCR or RTX maintained high rates of both clinical remission and radiological stability, and a washout shorter than four weeks virtually eliminated relapses-demonstrating robust efficacy for BCDTs in this subgroup.
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Registered trials
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