Evidence map›Paper›PMID 40739363›Full record

ArticleNeuroscience bulletin2026

Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques.

Qinyao Sun, Shunli Zhu, Futing Yang, Zhigang Chen, Heling Li, Heng Shao, Hong Wang, Sangma Xie, Jiaojian Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qinyao Sun *School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
Shunli Zhu *School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
Futing Yang *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China.
Zhigang ChenState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China.
Heling LiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China.
Heng ShaoDepartment of Geriatrics, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China. shaoheng90@sina.com.
Hong WangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China. wangh@lpbr.cn.
Sangma XieInstitute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou, 310018, China. smxie@hdu.edu.cn.
Jiaojian WangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China. jiaojianwang@uestc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The temporal pole (TP), one of the most expanded cortical regions in humans relative to other primates, plays a crucial role in human language processing. It is also one of the most structurally and functionally asymmetric regions. However, whether the functional architecture of the TP is shared by humans and macaques is an open question. We used spectral clustering algorithms to define a cross-species fine-grained TP atlas with different anatomical connectivity patterns. We identified three similar subregions, two ventral and one dorsal, within the TP in both humans and macaques. The parcellation scheme for the TP was validated using functional gradient mapping, anatomical connectivity and resting-state functional connectivity pattern analysis, and functional characterization. Furthermore, in conjunction with the Allen Human Brain Atlas, we revealed the molecular basis for the functional connectivity patterns of each human TP subregion. In addition, we compared the hemispheric asymmetry in mean gray matter volume, anatomical connectivity fingerprints, and whole brain functional connectivity patterns to reveal the evolutionary differences in the TP and found different asymmetric patterns between humans and macaques. In conclusion, our findings reveal that the asymmetry in structure and connectivity may underpin the hemispheric functional specialization of the brain and provide a novel insight into understanding the evolutionary origin of the TP.

Indexed as

Brain MappingFunctional LateralityTemporal LobeAdultAnimalsAtlases as TopicBrainFemaleHumansMacacaMagnetic Resonance ImagingMaleNeural PathwaysSpecies SpecificityYoung AdultAsymmetryEvolutionHumanMacaqueParcellationTemporal pole

Identifiers

PMID40739363
PMCPMC12789327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.