Evidence map›Paper›PMID 40739344›Full record

ArticleNature2025

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry.

Debasish Paul, Derek L Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C Abbate, Lisa M M Jenkins, Michael J Emanuele, Thorkell Andresson, Jing Huang and 3 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Debasish PaulLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Derek L BolhuisDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-9062-9739
Hualong YanLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-1676-9140
Sudipto DasProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Xia XuProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Christina C AbbateDepartment of Molecular and Cellular Biology, University of California, Davis, CA, USA.ORCID 0000-0001-8976-1882
Lisa M M JenkinsLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-1245-1338
Michael J EmanueleDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-4104-7449
Thorkell AndressonProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jing HuangLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-7163-5156
John G AlbeckDepartment of Molecular and Cellular Biology, University of California, Davis, CA, USA.
Nicholas G BrownLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6141-0164
Steven D CappellLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. steven.cappell@nih.gov.ORCID 0000-0002-2885-7327

Funding

MOLECULAR AND CELLULAR BIOPHYSICS TRAINING PROGRAMT32GM008570 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A, SLEP, KEVIN C · 1995 to 2022
$5.1M
Control of cell cycle commitment by APCC-Cdh1ZIABC011830 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CAPPELL, STEVEN · 2018 to 2025
$4.7M
Spindle Assembly Checkpoint SilencingR35GM128855 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nicholas Gene Brown · 2018 to 2026
$4.1M
Proteostasis signaling in cell cycle controlR35GM153250 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael James Emanuele · 2024 to 2026
$1.9M
Intramural NIH HHS ZIA BC011830NIGMS NIH HHS R35 GM128855NIGMS NIH HHS R35 GM153250NIGMS NIH HHS T32 GM008570
6 · The paper itself

Abstract

Mammalian cells entering the cell cycle favour glycolysis to rapidly generate ATP and produce the biosynthetic intermediates that are required for rapid biomass accumulation

Indexed as

Anaphase-Promoting Complex-CyclosomeCell CycleGlycolysisTOR Serine-Threonine KinasesAnimalsAntigens, CDCadherinsCdh1 ProteinsHumansMiceOxidative PhosphorylationPhosphofructokinase-2PhosphorylationAnaphase-Promoting Complex-CyclosomeAntigens, CDCadherinsCDH1 protein, humanCdh1 ProteinsFZR1 protein, humanMTOR protein, humanPFKFB3 protein, humanPhosphofructokinase-2TOR Serine-Threonine Kinases

Identifiers

PMID40739344
PMCPMC12488482

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.