ArticleNature2025
Diffusing protein binders to intrinsically disordered proteins.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
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47citing papers in PubMed
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Mapping the functional dark proteome in cancer.Nature reviews. Cancer · 2026Review
- The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026Review
- Reimagining computational macromolecular modeling: AI-driven approaches.Biophysical journal · 2026Review
- Mechanistic Interpretability of Protein Language Models Reveals Encoded Structural and Functional Properties of Intrinsically Disordered Proteins.bioRxiv : the preprint server for biology · 2026Article
- Article
- Sequence and structural determinants of efficacious de novo chimaeric antigen receptors.Nature biomedical engineering · 2026Article
- Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins.Biochemistry and biophysics reports · 2026Review
- Intracellular protein binders for imaging, control and future therapeutics.Nature biomedical engineering · 2026Review
- Diffusion-Based Protein Structure Design: Geometric Modelling, Validation Strategies, and Thermodynamic Challenges.International journal of molecular sciences · 2026Review
- RINAMI: Residue-attributed interpretable neural network for predicting absolute folding free energy by merging structure and sequence information.Protein science : a publication of the Protein Society · 2026Article
- AI-discovered protein fragments as generalizable regulators of biomolecular condensates.bioRxiv : the preprint server for biology · 2026Article
- Chemical adaptation: bridging synthetic chemistry with drug development.Science China. Life sciences · 2026Review
- What will be the future of computational biology for macromolecules in the era of AI?PLoS computational biology · 2026Article
- Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Modular Input-Output Biosensor Design UsingACS sensors · 2026Article
- Beyond Fungitoxicity: Recent Achievements in Targeted Fungicide Discovery.Journal of fungi (Basel, Switzerland) · 2026Review
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026Review
- Protein design and RNA design: Perspectives.Quantitative biology (Beijing, China) · 2026Article
Corrections and comments
- Update of
Authors and funding
32 authors.
Caixuan Liu *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1954-0731
Kejia Wu *Department of Biochemistry, University of Washington, Seattle, WA, USA. kejiawu@uw.edu.ORCID http://orcid.org/0000-0002-4532-4290
Hojun Choi *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8657-9548
Hannah L HanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4787-5168
Xueli ZhangKey Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Joseph L WatsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Green AhnDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jason Z ZhangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Sara ShijoDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Lydia L GoodCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5308-8542
Charlotte M FischerCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9473-2912
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5487-0499
Evans BrackenbroughDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6910-6255
Derrick R HickDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2950-1848
Seema QamarCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Justin DecarreauDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Stacey R GerbenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Wei YangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Dionne VafeadosInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2560-8907
Xinru WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5994-707X
Mila LambDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Analisa MurrayDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1560-6673
Sebastian KennyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Magnus S BauerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6449-0243
Ping ZhuKey Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-2648-3170
Tuomas P J KnowlesCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7879-0140
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MX-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6MQuantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesU01DK137097 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE, Michael MacCoss · 2023 to 2026
$3.4MDe novo designed Ras tools to uncover the mechanisms underlying drug resistanceK99CA293001 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, JASON · 2024 to 2024
$110kNCI NIH HHS K99 CA293001NIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK137097NIGMS NIH HHS P30 GM133893
Abstract
Proteins that bind to intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could be useful for therapeutic and diagnostic applications
Indexed as
Intrinsically Disordered ProteinsAmyloidHumansIslet Amyloid PolypeptideLysosomesModels, MolecularPrion ProteinsProtein BindingRNA Recognition Motif ProteinsAmyloidIntrinsically Disordered ProteinsIslet Amyloid PolypeptidePrion ProteinsRNA Recognition Motif Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.