Evidence map›Paper›PMID 40739299›Full record

ArticleNPJ Parkinson's disease2025

Video analysis reveals early signs of Bradykinesia in REM sleep behavior disorder and Parkinson's disease.

Diego L Guarín, Gabriela Acevedo, Carolina Calonge, Joshua K Wong, Nikolaus R McFarland, Adolfo Ramirez-Zamora, David E Vaillancourt

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diego L GuarínDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA. d.guarinlopez@ufl.edu.
Gabriela AcevedoDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Carolina CalongeDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Joshua K WongFixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
Nikolaus R McFarlandFixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
Adolfo Ramirez-ZamoraFixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL, USA.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.

Funding

Role of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1M
NIA NIH HHS 5R01NS058487NINDS NIH HHS 5R01NS058487NINDS NIH HHS R01 NS058487
6 · The paper itself

Abstract

Idiopathic REM sleep behavior disorder (iRBD) is a strong predictor of neurodegenerative diseases like Parkinson's disease (PD). Early detection of motor impairments such as bradykinesia is critical for identifying at-risk populations. This study analyzed Finger Tapping Task videos from 66 participants, including healthy controls (HC) and individuals with iRBD and PD. Only videos that received a clinician score of zero on the MDS-UPDRS Part-III finger tapping item were analyzed. Movement amplitude, speed, and their decrements during the task were directly estimated from the videos using machine learning algorithms. Bradykinesia and hypokinesia were detectable in PD but not in iRBD, while decrement in movement amplitude and speed were observed in PD and iRBD. Classification models achieved 81.5% accuracy distinguishing PD from HC, 79.8% distinguishing iRBD from HC, and 81.7% differentiating iRBD from PD. Video-based assessments offer a low-cost, scalable solution for supporting the identification individuals at risk of developing neurodegenerative diseases.

Identifiers

PMID40739299
PMCPMC12311115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.