Evidence map›Paper›PMID 40739297›Full record

ArticleNPJ Parkinson's disease2025

Effect of high, low, and asymmetric frequency subthalamic stimulation on speech and voice in Parkinson's disease: a randomized trial.

Zhitong Zeng, Mei Yang, Zhengyu Lin, Peng Huang, Yixin Pan, Chencheng Zhang, Bomin Sun, Dianyou Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhitong Zeng *Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mei Yang *Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhengyu Lin *Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peng HuangDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yixin PanDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chencheng ZhangClinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bomin SunDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dianyou LiDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ldy11483@rjh.com.cn.

Funding

National Natural Science Foundation of China 82301664Science and Technology Commission of Shanghai Municipality 22Y11903900Shanghai Municipal Health Commission 202140181Shanghai Youth Science and Technology Talents Sailing projects 23YF1424000
6 · The paper itself

Abstract

While bilateral high-frequency subthalamic nucleus stimulation (Bi-HFS) frequently worsens speech in Parkinson's disease (PD), low-frequency stimulation (LFS) may alleviate gait deficits but lacks robust evidence for speech benefits. This randomized trial compared Bi-LFS (60 Hz) and Bi-HFS (130 Hz) in 33 PD patients with postural instability/gait difficulty (PIGD), and evaluated asymmetric frequency stimulation (AFS) in 20 patients. Bi-LFS significantly improved dysphonia severity index (DSI, FDR-p = 0.024), maximum phonation time (MPT, FDR- p = 0.025), and subjective speech ratings compared to Bi-HFS. Left-LFS/right-HFS (L-LFS/R-HFS) matched Bi-LFS efficacy and surpassed Bi-HFS in objective measures (FDR-p ≤ 0.021). Speech improvements correlated with motor/gait gains, independent of tremor. Findings suggest Bi-LFS mitigates speech dysfunction in PIGD-PD, with left-sided LFS potentially driving benefits, while AFS provides comparable outcomes. These data support tailored stimulation protocols to optimize speech in PD. The National Medical Research Registration and Information System of China (MR-31-23-036810).

Identifiers

PMID40739297
PMCPMC12311008

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.