ArticleJournal of neuroinflammation2025
Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma.
Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Chronic high-altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular-immune-neuronal network.Neuroprotection (Chichester, England) · 2026Review
- Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.Translational stroke research · 2026Review
- Article
- Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312.Annals of clinical and translational neurology · 2026Article
- Correction: Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single‑cell RNA sequencing: from blood to hematoma.Journal of neuroinflammation · 2026Article
- Natural killer T cells in intracerebral hemorrhage: phase-dependent immune responses and therapeutic implications.Frontiers in immunology · 2026Review
- Non-invasive vagus nerve magnetic stimulation combined with rehabilitation training for vocal cord paralysis and dysphagia following brain injury: a prospective case series study.Frontiers in neurologyArticle
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs limited medical interventions proved efficacy in intracerebral hemorrhage (ICH), the mechanisms underlying primary and secondary tissue injury remain poorly understood based on hematoma. In this study, we aimed to investigate the transcriptional profiles of immune cells from hematoma samples derived from ICH patients, which was rarely focused before.
methodsSingle cell RNA sequencing (scRNA-seq) was performed on hematoma and blood samples derived from ICH patients, with blood samples from healthy volunteers serving as a control. Subsequent comprehensive analyses, including cell-cell communication and trajectory inference, were conducted to provide a detailed understanding of immune cell characteristics in ICH.
resultsHematoma and blood samples were derived from four ICH patients, with blood samples from three healthy volunteers as control. At the single-cell level, three major immune cell types were identified, with neutrophils playing a predominant role. Subtypes of these immune cells were further characterized based on their profiles in hematoma and blood samples. The role of Toll-like receptor 4 in hematoma in ICH was further investigated from the perspective of immune inflammation and metabolism.
conclusionThis study offers a comprehensive overview of the immune cell landscape in ICH, derived from hematoma and blood samples, which has been rarely reported. The dynamic inflammatory processes involving distinct immune cell types were further elucidated, and provides potential therapeutic targets for future interventions.
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