Evidence map›Paper›PMID 40739248›Full record

ArticleBMC chemistry2025

Synthesis, molecular modeling and harnessing the antimicrobial activity of new pyrazine-thiadiazole hybrids.

Hana M Abumelha, Nuha M Halawani, Abdulrahman S Alharbi, Rabah N Alsulami, Jihan Qurban, Khadra B Alomari, Ameena M Al-Bonayan, Nashwa El-Metwaly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hana M AbumelhaDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Nuha M HalawaniDepartment of Chemistry, Faculty of Science, Umm Al Qura University, 24230, Makkah, Saudi Arabia.
Abdulrahman S AlharbiDepartment of Chemistry, College of Science and Humanities-Dawadmi, Shaqra University, 17452, Dawadmi, Saudi Arabia.
Rabah N AlsulamiDepartment of Biology, College of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Jihan QurbanDepartment of Chemistry, Faculty of Science, Umm Al Qura University, 24230, Makkah, Saudi Arabia.
Khadra B AlomariDepartment of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box 114, 45142, Jazan, Saudi Arabia.
Ameena M Al-BonayanDepartment of Chemistry, Faculty of Science, Umm Al Qura University, 24230, Makkah, Saudi Arabia.
Nashwa El-MetwalyDepartment of Chemistry, Faculty of Science, Umm Al Qura University, 24230, Makkah, Saudi Arabia. n_elmetwaly00@yahoo.com.

Funding

Princess Nourah Bint Abdulrahman University PNURSP2025R22
6 · The paper itself

Abstract

Various pyrazine-substituted thiadiazole hybrid compounds 5a-c, 9a-c, and 11a-c have been synthesized and elucidated using spectral measurements. Despite the alternative spatial structures, the DFT modeling of the targeting hybrids revealed comparable HOMO-LUMO configurations and energies, which were employed in the estimation of some chemical reactivity parameters. Further, the antimicrobial efficacy of these hybrids was measured against bacterial and fungal strains. Hybrids 5b, 5c, and 9c demonstrated effective antimicrobial activities, comparable to reference drugs. Hybrid 5b exhibited broad-spectrum activity, while 9c showed the strongest antifungal effectiveness. Moreover, in vitro assessment of dihydrofolate reductase (DHFR) enzyme inhibition revealed notable activity; hybrid 9c demonstrated the highest potency (IC

Indexed as

ADMETAntimicrobialDHFRHydrazonoyl bromideModelingPyrazine-thiadiazole

Identifiers

PMID40739248
PMCPMC12312595

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.