Evidence map›Paper›PMID 40739232›Full record

ArticleMalaria journal2025

Larvicidal and adulticidal effects of Ethiopian medicinal plants against Anopheles gambiae (Diptera: Culicidae).

Sileshi Tadesse, Solomon Mequanente Abay, Eyasu Makonnen, Abebe Ejigu, Yehenew Asemamaw, Werissaw Haileselassie, Ephrem Engidawork

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sileshi TadesseDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Solomon Mequanente AbayDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.ORCID http://orcid.org/0000-0002-7844-3771
Eyasu MakonnenDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.ORCID http://orcid.org/0000-0002-8834-9949
Abebe EjiguDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Yehenew AsemamawDepartment of Microbiology, Parasitology and Immunology, School of Medicine, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Werissaw HaileselassieSchool of Public Health, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Ephrem EngidaworkDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia. ephrem.engidawork@aau.edu.et.ORCID http://orcid.org/0000-0002-9931-6421

Funding

Addis Ababa University Thematic Research
6 · The paper itself

Abstract

backgroundThe malaria control programmes are facing a challenge due to a rapidly increasing resistance to currently available synthetic insecticides. Medicinal plants offer a promising alternative for mosquito control, addressing environmental and resistance concerns. The study aimed to assess the larvicidal and adulticidal effects of crude extracts and fractions of selected Ethiopian medicinal plants.

methodsMethanol crude extract/fractions of leaves of Croton macrostachyus (Euphorbiaceae) and Dodonaea angustifolia (Sapindaceae), rhizomes of Kniphofia foliosa (Asphodelaceae) and roots of Rumex abyssinicus (Polygonaceae) were tested for their larvicidal and adulticidal activity against late 3rd to early 4th instar larvae and 3 to 5 days adults of Anopheles gambiae, respectively. For both assays, the plants were incubated with the parasites for 48 h at concentrations of 25, 50, 100, 200, and 400 ppm. Percent mean mortality rate was compared using one-way ANOVA, and LC

resultsCroton macrostachyus crude extract exhibited the strongest activity, achieving 100% mortality rate at 400 ppm, with LC

conclusionsThe crude extract and ethyl acetate fractions of C. macrostachyus as well as the rhizome of K. foliosa showed a promising biopesticide activity that could further be developed for malaria vector control.

Indexed as

AnophelesInsecticidesPlant ExtractsPlants, MedicinalAnimalsEthiopiaLarvaSurvival AnalysisInsecticidesPlant ExtractsAdulticidalAnopheles gambiaeEthiopiaLarvicidalMedicinal plants

Identifiers

PMID40739232
PMCPMC12312548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.