Evidence map›Paper›PMID 40739210›Full record

SynthesisBMC oral health2025

Deep learning for tooth detection and segmentation in panoramic radiographs: a systematic review and meta-analysis.

M Bonfanti-Gris, A Herrera, M P Salido Rodríguez-Manzaneque, F Martínez-Rus, G Pradíes

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M Bonfanti-GrisDepartment of Conservative and Prosthetic Dentistry, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.
A HerreraDepartment of Conservative and Prosthetic Dentistry, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.
M P Salido Rodríguez-ManzanequeDepartment of Conservative and Prosthetic Dentistry, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain. mpsalido@ucm.es.
F Martínez-RusDepartment of Conservative and Prosthetic Dentistry, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.
G PradíesDepartment of Conservative and Prosthetic Dentistry, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review and meta-analysis aimed to summarize and evaluate the available information regarding the performance of deep learning methods for tooth detection and segmentation in orthopantomographies. MATERIAL AND

methodsElectronic databases (Medline, Embase and Cochrane) were searched up to September 2023 for relevant observational studies and both, randomized and controlled clinical trials. Two reviewers independently conducted the study selection, data extraction, and quality assessments. GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) assessment was adopted for collective grading of the overall body of evidence. From the 2,207 records identified, 20 studies were included in the analysis. Meta-analysis was conducted for the comparison of mesiodens detection and segmentation (n = 6) using sensitivity and specificity as the two main diagnostic parameters. A graphical summary of the analysis was also plotted and a Hierarchical Summary Receiver Operating Characteristic curve, prediction region, summary point, and confidence region were illustrated.

resultsThe included studies quantitative analysis showed pooled sensitivity, specificity, positive LR, negative LR, and diagnostic odds ratio of 0.92 (95% confidence interval [CI], 0.84-0.96), 0.94 (95% CI, 0.89-0.97), 15.7 (95% CI, 7.6-32.2), 0.08 (95% CI, 0.04-0.18), and 186 (95% CI, 44-793), respectively. A graphical summary of the meta-analysis was plotted based on sensitivity and specificity. Hierarchical Summary Receiver Operating Characteristic curves showed a positive correlation between logit-transformed sensitivity and specificity (r = 0.886).

conclusionsBased on the results of the meta-analysis and GRADE assessment, a moderate recommendation is advised to dental operators when relying on AI-based tools for tooth detection and segmentation in panoramic radiographs.

Indexed as

Deep LearningRadiography, PanoramicToothHumansSensitivity and SpecificityArtificial intelligenceConvolutional neural networkDeep learningDentistryOrthopantomographyPanoramic radiograph

Identifiers

PMID40739210
PMCPMC12312236

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.