Evidence map›Paper›PMID 40739196›Full record

ArticleBMC cardiovascular disorders2025

The lack of evidence-based management in electrical storm: a scoping review.

Pouya Motazedian, Graeme Prosperi-Porta, Marie-Eve Mathieu, Nickolas Beauregard, William Knoll, Nicholas Quinn, Simon Parlow, Pietro Di Santo, Omar Abdel-Razek, Richard Jung and 9 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pouya Motazedian *CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Graeme Prosperi-Porta *CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Marie-Eve MathieuCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Nickolas BeauregardSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
William KnollDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Nicholas QuinnDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Simon ParlowCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Pietro Di SantoCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Omar Abdel-RazekCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Richard JungCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Nikola KolobaricFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
William BarbourFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
David NelsonDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Trevor SimardDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Jacob C JentzerDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Rebecca MathewCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
George A WellsDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
F Daniel Ramirez *CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Benjamin Hibbert *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. Hibbert.Benjamin@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical storm (ES) is associated with a significant risk of morbidity and mortality. Despite this, there has been limited research in ES resulting in uncertainty and inconsistency in the management of this life-threatening condition. The objective of this scoping review was to define the current body of literature evaluating pharmacologic and non-pharmacologic therapies used in the management of ES. A comprehensive search of Medline, CENTRAL and Embase was completed on January 11, 2025. Primary studies on pharmacotherapies in ES were included if they reported therapy-related outcomes and included ≥ 5 adult patients. A total of 45 studies met the inclusion criteria. Four studies were randomized control trials (three trials had overlapping cohorts) and the remaining were observational studies. Amiodarone, quinidine, landiolol, isoproterenol, and mexiletine were the most studied medications. The use of sedation for ES was exclusively studied in the context of mechanical ventilation. There was an increase in the number of ES studies over time, but sample sizes remained small and unchanged. Existing evidence to guide the management of ES is predominantly based on small observational studies. High quality data to inform the management of ES is needed.

Indexed as

Anti-Arrhythmia AgentsEvidence-Based MedicineHeart Conduction SystemHeart RateTachycardia, VentricularHumansRisk FactorsTreatment OutcomeAnti-Arrhythmia AgentsElectrical stormEvidence-based medicinePharmacologic managementVentricular tachycardia

Identifiers

PMID40739196
PMCPMC12308950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.