Evidence map›Paper›PMID 40739186›Full record

Observational studyBMC anesthesiology2025

An observational laboratory study to evaluate an anesthetic gas adsorber without anesthetic gas scavenging system.

Katja Nickel, Christian Thoben, Christiane E Beck, Jan Karsten, Terence Krauß, Alexander Nitschke, Moritz Hitzemann, Stefan Zimmermann, Sebastian Heiderich

Abstract readObservational Study
In one paragraph

Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katja Nickel *Clinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. nickel.katja@mh-hannover.de.
Christian Thoben *Institute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Leibniz University Hannover, Hannover, Germany.
Christiane E BeckClinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Jan KarstenClinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Terence KraußClinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Alexander NitschkeInstitute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Leibniz University Hannover, Hannover, Germany.
Moritz HitzemannInstitute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Leibniz University Hannover, Hannover, Germany.
Stefan ZimmermannInstitute of Electrical Engineering and Measurement Technology, Department of Sensors and Measurement Technology, Leibniz University Hannover, Hannover, Germany.
Sebastian HeiderichClinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolatile anesthetics are known to be potent greenhouse gases and a significant source of per-and polyfluoroalkyl substances (PFAS) "forever chemical" pollution. The latter is arguably an additional strong reason to stop the emission of anesthetic exhaust gases into the atmosphere on its own. In clinical practice large proportions of used volatile anesthetics are released into the environment via anesthetic gas scavenging systems. Anesthetic gas adsorbers have been developed to bind volatile anesthetics for later extraction and reusage. They may have the potential to replace anesthetic gas scavenging systems which would have a beneficial effect on the energy consumption of hospitals. However, studies are needed to ensure effective elimination of volatile anesthetics via anesthetic gas adsorbers without gas scavenging systems.

objectiveTo evaluate an anesthetic gas adsorber during simulated ventilation.

designA bench study.

settingAn anesthesia machine was connected to an anesthetic gas adsorber (CONTRAfluran™ system, Zeosys Medical, Luckenwalde, Germany) without the use of an anesthetic gas scavenging system. A test lung was ventilated with sevoflurane and oxygen. Sevoflurane concentrations in parts per million (ppm) were detected directly from the anesthetic gas adsorber exhaust outlet using ion mobility spectrometry with gas chromatographic preseparation. A total of 6 experiments were conducted with alternating fresh gas flows, sevoflurane concentrations, humidified air and CO

main outcome measuresAbsolute sevoflurane concentration.

resultsSevoflurane concentration remained < 1 ppm as long as the canisters were not saturated. At higher fresh gas flow, the breakthrough time of the anesthetic gas adsorber decreased proportionately. Humidified air and CO

conclusionThe anesthetic gas adsorber did not leak relevant sevoflurane concentrations through the exhaust outlet when used without an anesthetic gas scavenging system. When the canister came close to saturation, the post adsorber exhaust sevoflurane concentration progressively increased-indicated by first the yellow-light and subsequently the red-light warning of the anesthetic gas adsorber system. Continuation of the ventilation with a fully saturated canister resulted in ambient room contamination of up to 12.4 ppm sevoflurane, which though undesirable is still low when compared to mask induction.

Indexed as

Anesthetics, InhalationGas ScavengersMethyl EthersAdsorptionHumansSevofluraneAnesthetics, InhalationMethyl EthersSevofluraneAnesthetic gas adsorberAnesthetic gas scavenging systemFresh gas flowGlobal warming potentialsIon mobility spectrometrySevofluraneVolatile anesthetics

Identifiers

PMID40739186
PMCPMC12312432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.