Evidence map›Paper›PMID 40739139›Full record

Trial reportSignal transduction and targeted therapy2025

Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial.

Yi Liu, Yitong Liu, Jingchao Hu, Jianhui Han, Lin Song, Xu Liu, Nannan Han, Xia Xia, Jia He, Hongfang Meng and 7 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yi Liu *Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China. lililiuyi@163.com.
Yitong Liu *Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Jingchao Hu *Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Jianhui HanDepartment of Radiology, School of Stomatology, Capital Medical University, Beijing, China.
Lin SongLaboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Xu LiuLaboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Nannan HanLaboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Xia Xia *Beijing SH Biotechnology Co. Ltd., Beijing, China.
Jia HeBeijing SH Biotechnology Co. Ltd., Beijing, China.
Hongfang MengBeijing SH Biotechnology Co. Ltd., Beijing, China.
Meng Wan *Department of Stomatology, Peking University Third Hospital, Beijing, China.
Haojie WangDepartment of Stomatology, Peking University Third Hospital, Beijing, China.
Xiaodan LiuDepartment of Stomatology, Peking University Third Hospital, Beijing, China.
Zhanyi GaoDepartment of Stomatology, Peking University Third Hospital, Beijing, China.
Xiao WangDepartment of Stomatology, Peking University Third Hospital, Beijing, China. bysywangxiao@163.com.
Chutse WuBeijing SH Biotechnology Co. Ltd., Beijing, China. 13910026365@163.com.
Songlin WangBeijing Laboratory of Oral Health, Capital Medical University, Beijing, China. slwang@ccmu.edu.cn.ORCID 0000-0002-7066-2654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis causes the destruction of tooth-supporting tissues, and current therapies for periodontal regeneration are invasive. In this study, a human dental pulp stem cell (DPSC; hDP-MSC) injection was developed to promote periodontal regeneration through a non-invasive procedure. A total of 132 patients with chronic periodontitis (158 teeth) from two centers in China were included. Thirty-six were randomly assigned to different DPSC dose groups (ranging from 1 × 10

Indexed as

Chronic PeriodontitisDental PulpPeriodontitisRegenerationStem CellsStem Cell TransplantationAdultFemaleHumansMaleMiddle Aged

Identifiers

PMID40739139
PMCPMC12311062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.