ArticleNature communications2025
Transposons and accessory genes drive adaptation in a clonally evolving fungal pathogen.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- Fungal DNA damage repair: from model to driver of virulence and AMR.Bioscience reports · 2026Review
- Microsatellite Markers Display High Diversity in Bean Anthracnose Pathogen Colletotrichum lindemuthianum in Kashmir.Biochemical genetics · 2026Article
- Whole-Genome Resequencing Reveals Genetic Variation and Selection Signals inJournal of fungi (Basel, Switzerland) · 2026Article
- Mobile Genetic Elements as Key Drivers of Bacterial Evolution and Adaptation in Agroecosystems.Microbial ecology · 2026Review
- Article
- TrichoBase: a standardized genomic resource for comparative genomics of Trichoderma species.BMC genomic data · 2026Article
- The dynamics of transposable element content in the genome of the human pathogen Histoplasma.Fungal genetics and biology : FG & B · 2026Article
- Comparative Genomics Reveals Host-Specific Adaptation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Genomic Insights into Historical Adaptation of Three Key Fungal Plant Pathogens.Genome biology and evolution · 2025Article
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Authors and funding
6 authors.
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Abstract
Genomes of clonally reproducing fungal pathogens are often compartmentalized into conserved core and lineage-specific accessory regions (ARs), enriched in transposable elements (TEs). ARs and TEs are thought to promote pathogen adaptation, but direct experimental evidence is sparse. Using an evolve and re-sequence approach, we found that serial passaging of the cross-kingdom fungal pathogen Fusarium oxysporum through tomato plants or axenic media rapidly increased fitness under the selection condition. TE insertions were the predominant type of mutations in the evolved lines, with a single non-autonomous hAT-type TE accounting for 63% of total events detected. TEs are inserted preferentially at sites of histone H3 lysine 27 trimethylation, a hallmark of ARs. Recurrent evolutionary trajectories during plate adaptation led to increased proliferation concomitant with reduced virulence. Unexpectedly, adaptive mutations in accessory genes strongly impacted core functions such as growth, development, quorum sensing, or virulence. Thus, TEs and ARs drive rapid adaptation in this important fungal pathogen.
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