SynthesisArchives of gynecology and obstetrics2025
Oxidative stress biomarkers in fetal growth restriction: a systematic review and meta-analysis.
Synthesis in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Impact of early versus delayed cord clamping on oxidative stress in neonates with intrauterine growth restriction: a prospective randomized controlled trial.BMC pregnancy and childbirth · 2025Trial
- Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes-A Prospective Cohort Study.Antioxidants (Basel, Switzerland) · 2026Article
- Longitudinal Assessment of Oxidative Stress Biomarkers During Physiological Pregnancy and Their Relevance for Maternal Healthcare.Healthcare (Basel, Switzerland) · 2026Article
- Elevated Amniotic Fluid 8-Iso-Prostaglandin FAntioxidants (Basel, Switzerland) · 2026Article
- Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review).International journal of molecular medicine · 2026Review
- Placental mesenchymal dysplasia: diagnostic and management insights from a case report and literature review.Archives of gynecology and obstetrics · 2026Review
- Common Biomarkers of Endothelial Dysfunction Across Highly Prevalent Diseases with Cardiovascular Risk: Functional Characterization and Prognostic Implications.International journal of molecular sciences · 2026Article
- Prenatal Benzydamine Exposure Induces Fetal Growth Restriction and Maternal Oxidative Stress in Rats.International journal of molecular sciences · 2026Article
- Trimester-specific exposure to PMBMC pregnancy and childbirth · 2026Article
- Beyond biometry: the role of fetal venous doppler in discriminating fetal growth restriction from small for gestational age and predicting adverse perinatal outcomes.BMC pregnancy and childbirth · 2026Article
- From Fetal Growth Restriction to Adolescent Cardiometabolic Risk: The Impact of Catch-Up Growth and Adiposity.Nutrients · 2026Article
- Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.International journal of molecular sciences · 2026Review
- Increased Serum Signal Peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial Growth Factor Domain-Containing Protein-1 May Have a Role in the Pathophysiology of Late-Onset Fetal Growth Restriction.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFetal growth restriction (FGR) affects about 10% of pregnancies and is linked to higher risks of perinatal mortality and long-term health issues, largely due to placental insufficiency and oxidative stress caused by hypoxia and inflammation. This study examines key oxidative stress biomarkers to assess significant differences in FGR versus appropriate for gestational age (AGA) neonates.
methodsThis meta-analysis reviewed studies up to December analyzing oxidative stress biomarkers in cord blood from FGR versus AGA newborns. Key markers analyzed included malondialdehyde (MDA), superoxide dismutase (SOD), catalase, ischemia-modified albumin (IMA), homocysteine, nitric oxide (NO), and nucleated red blood cells (NRBCs). Standardized mean differences (Cohen's d) and 95% confidence intervals (CIs) were calculated.
resultsA total of 48 studies involving 4684 participants were included. MDA levels were significantly higher in FGR infants (d = 0.37, p = 0.01), especially in those with intrauterine growth restriction (IUGR) (d = 0.58, p = 0.02). SOD activity was markedly lower in FGR (d = - 1.98, p < 0.001), most notably in mixed FGR cases (d = - 4.95). Catalase was also reduced (d = - 2.64, p < 0.001), while NRBC (d = 2.24, p < 0.001) and IMA (d = 0.74, p < 0.001) were elevated. Homocysteine and NO levels showed no significant differences.
conclusionFGR is associated with distinct oxidative stress patterns in cord blood. These biomarkers, especially MDA, SOD, catalase, NRBC, and IMA, may hold promise for improving FGR diagnosis.
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