Evidence map›Paper›PMID 40739044›Full record

ArticleBiomolecular NMR assignments2025

Nina M Krause, Anna Wacker, Christian Richter, Boris Fürtig, Ramakanth Madhugiri, John Ziebuhr, Harald Schwalbe

Abstract read
In one paragraph

Article in Biomolecular NMR assignments, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nina M KrauseInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße7, 60438, Frankfurt/M, Germany.
Anna WackerInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße7, 60438, Frankfurt/M, Germany.
Christian RichterInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße7, 60438, Frankfurt/M, Germany.
Boris FürtigInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße7, 60438, Frankfurt/M, Germany.
Ramakanth MadhugiriInstitute of Medical Virology, Justus Liebig University, Giessen, Germany.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University, Giessen, Germany.
Harald SchwalbeInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße7, 60438, Frankfurt/M, Germany. schwalbe@nmr.uni-frankfurt.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the emergence of the SARS-CoV-2 virus, research on coronaviruses has been massively accelerated. In addition to SARS-CoV-2, there are other human coronaviruses, including HCoV-229E. In all coronaviruses, secondary structure predictions indicate the presence of conserved structural elements in the 5'-untranslated region (5'-UTR). These conserved elements play crucial roles in RNA translation and replication. Stem-loop 5 (SL5), consisting of three substructures (5a, 5b, 5c), is highly conserved and harbours the start codon for translation. SL5 has repetitive structural motifs (RSMs), 5'-UUYYGU-3', which are conserved in many alpha- and betacoronaviruses. In the following, we present the

Indexed as

5' Untranslated RegionsCoronavirus 229E, HumanNuclear Magnetic Resonance, BiomolecularRNA, ViralBase SequenceCarbon IsotopesHumansNitrogen IsotopesNucleic Acid Conformation5' Untranslated RegionsCarbon-13Carbon IsotopesNitrogen-15Nitrogen IsotopesRNA, Viral5‘-UTRCoronavirusesHCoV-229ESL5aSolution NMR spectroscopy

Identifiers

PMID40739044
PMCPMC12513883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.