Evidence map›Paper›PMID 40738923›Full record

ArticleScientific reports2025

Eco‑friendly biosynthesis of gold nanoparticles from Amphimedon compressa with antibacterial, antioxidant, anti-inflammatory, anti-biofilm, and insecticidal properties against diseases vectors.

Alsayed E Mekky, Ebrahim Saied, Mahmoud M Al-Habibi, Zeinab A Shouaib, Ahmed I Hasaballah, Mohammed E Rashed, Ashjan F Khalel, Amal Naif Alshammari, Fady Sayed Youssef, Ahmed M Al-Shahat and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alsayed E MekkyBotany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr, Cairo, 11884, Egypt.
Ebrahim SaiedBotany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr, Cairo, 11884, Egypt.
Mahmoud M Al-HabibiMicrobiology and Immunology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Zeinab A ShouaibZoology and Entomology Department, Faculty of Science, (Girls), Al-Azhar University, Nasr, Cairo, 11884, Egypt.
Ahmed I HasaballahZoology and Entomology Department, Faculty of Science (Boys), Al-Azhar University, Nasr, Cairo, 11884, Egypt.
Mohammed E RashedResearch Institute of Medical Entomology, Ministry of Health and Population, Dokki, Giza, Egypt.
Ashjan F KhalelBiology Department, Al-Darb University College, Jazan University, Jazan, Saudi Arabia.
Amal Naif AlshammariBiology Department, Al-Darb University College, Jazan University, Jazan, Saudi Arabia.
Fady Sayed YoussefPharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Ahmed M Al-ShahatZoology and Entomology Department, Faculty of Science (Boys), Al-Azhar University, Nasr, Cairo, 11884, Egypt.
Mohammad Y AlfaifiFaculty of Science, Biology Department, King Khalid University, 9004, Abha, Saudi Arabia.
Serag Eldin I ElbehairiFaculty of Science, Biology Department, King Khalid University, 9004, Abha, Saudi Arabia.
Mohammed AufyDepartmet of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna, Austria. mohammed.aufy@univie.ac.at.
Tharwat A SelimZoology and Entomology Department, Faculty of Science (Boys), Al-Azhar University, Nasr, Cairo, 11884, Egypt. tharwat3d@azhar.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) are increasingly recognized for their potential in biology due to their excellent drug delivery capabilities and ease of synthesis. To create AuNPs using marine sponge Amphimedon compressa, we used several techniques, including ultraviolet-visible (UV-visible) spectrophotometry, Fourier transform infrared (FTIR) spectrophotometry, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and x-ray diffraction (XRD). The UV-visible spectroscopy results demonstrated the formation of stable AuNPs at a pH of 7, with a peak absorption at 564 nm. FTIR spectroscopy indicated that secondary metabolites featuring -OH functional groups acted as reducing agents in the production of AuNPs. Morphological analysis showed that the AuNPs were spherical, consistently shaped particles averaging 10-40 nm in diameter, with proven stability over time. The inhibition zones for the bacteria tested with the synthesized AuNPs varied from 26 to 31 mm. Both the AuNPs and the A. compressa extract displayed significant antioxidant activity, achieving DPPH radical scavenging percentages of 70.73% and 85.62%, respectively. In terms of anti-inflammatory activity, the AuNPs showed dose-dependent anti-inflammatory activity, with hemolytic inhibition percentages of 4.8%, 10.2%, 12.8%, 14.9%, 19.5%, and 22.4% at increasing concentrations. Furthermore, both the crude extract and the synthesized AuNPs exhibited adulticidal activity against the house fly (Musca domestica) and the mosquito (Culex pipiens). The LC

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAntioxidantsGoldInsecticidesMetal NanoparticlesPoriferaAnimalsBiofilmsDisease VectorsGreen Chemistry TechnologyAnti-Bacterial AgentsAnti-Inflammatory AgentsAntioxidantsGoldInsecticidesAdulticidal activity, insecticidal propertiesAntibacterialBiosynthesis, anti-inflammatory, anti-biofilmMarine spongeNanotechnology, AuNPs

Identifiers

PMID40738923
PMCPMC12311194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.