ArticleAsia Pacific journal of clinical nutrition2025
Association between low vitamin B-12 status and latent tuberculosis infection among adults.
Article in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
objectivesTuberculosis (TB) remains a major public health threat worldwide, but most of the presumed infected individuals remain asymptomatic and contain Mycobacterium tuberculosis (MTB) in a latent tuberculosis infection (LTBI), and some of them will progress to active tuberculosis. Vitamin B-12 is crucial to maintain immune function, and play a role in the metabolism of MTB, while few studies investigated the impact of vitamin B-12 deficiency on tuberculosis. Therefore, we carried out the study to explore the association between vitamin B-12 deficiency and LTBI using the National Health and Nutrition Examination Surveys (NHANES). METHODS AND STUDY
designA cross-sectional study was conducted by using data from NHANES 2011-2012. Adults (aged ≥18 years) who had available data on serum Vitamin B-12, serum Methylmalonic Acid (MMA) and QuantiFERON-TB Gold In-Tube (QFT-GIT) results were included in the analysis. Multivariable logistic regression was used to assess the association between Vitamin B-12 deficiency and LTBI.
resultsA total of 4773 subjects were included in the present study, of whom 479 were screened as LTBI. The LTBI group had a higher proportion of participants with low Vitamin B-12 status. After adjusting for the possible confounders, Vitamin B-12 deficiency was independently associated with a 37% increased odds ratio of LTBI in the participants (OR: 1.37; 95% CI: 1.01-1.85). Similar correlations remained in subjects aged ≥35 years and female subjects by further stratified analysis.
conclusionsVitamin B-12 deficiency was significantly associated with higher prevalence of LTBI in US adults. Maintenance of optimal Vitamin B-12 status has potential benefits for LTBI prevention. Future studies are needed to assess the roles and clinical implications of Vitamin B-12 in MTB infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.