Evidence map›Paper›PMID 40738630›Full record

ArticleBMJ open2025

Randomised, controlled clinical trial evaluating the effects of preoperative insomnia treatment on postoperative pain control and recovery: a protocol for the Promoting Sleep to Alleviate Pain-Arthroplasty (PROSAP-A) trial.

Martin F Bjurström, Kristoffer Bothelius, Pernilla Maathz, Susanna Jernelöv, Martin Kraepelien, Alexander H C Rosenström, Andrea Niklasson, Michael T Smith, Richard Olmstead, Michael R Irwin and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06145516 (Preoperative Sleep-promotion to Achieve Improved Postoperative Pain Control and Recovery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06145516 narecruitingnot on this map

Preoperative Sleep-promotion to Achieve Improved Postoperative Pain Control and Recovery: a Randomized, Controlled Trial

TypeinterventionalSponsorUppsala UniversityRan2025 to 2030Enrolled100ConditionsOsteoarthritis, Knee, Osteoarthritis, Hip, Insomnia, SurgeryArmsCognitive behavioral therapy for insomnia (CBT-I), Sleep education therapy (SET)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Martin F BjurströmClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden martin.flores.bjurstrom@uu.se.ORCID http://orcid.org/0000-0001-5463-7742
Kristoffer BotheliusClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Pernilla MaathzClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Susanna JernelövCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Martin KraepelienCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Alexander H C RosenströmClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Andrea NiklassonClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Michael T SmithDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Richard OlmsteadDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Patrick H FinanDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Eva KosekClinical Pain Research, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSleep is a biological necessity with vital effects on all tissues and organs of the body. Preoperative sleep disturbance is associated with increased postoperative pain intensity and opioid consumption. Given that insomnia is a potentially modifiable risk factor, interventions targeting sleep prior to surgery may improve postoperative pain control and enhance key outcomes of recovery. METHODS AND ANALYSIS: Promoting Sleep to Alleviate Pain-Arthroplasty (PROSAP-A) is a randomised, parallel group, two arm, controlled trial evaluating the effects of preoperative sleep-promotion on postoperative pain control, brain health and physical recovery. The main objective is to investigate whether preoperative insomnia treatment in patients scheduled to undergo total knee arthroplasty (TKA) or total hip arthroplasty (THA) may improve acute postoperative pain control. 100 adults with insomnia disorder (Insomnia Severity Index score >10 and confirmed Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for persistent insomnia disorder), scheduled to undergo primary TKA or THA, will be randomised to preoperative cognitive behavioural therapy for insomnia (CBT-I) or an active comparator control intervention, sleep education therapy (SET). Both interventions will be delivered over 4 weeks in hybrid format through a digital self-guided platform in combination with weekly telehealth video sessions with a psychologist (CBT-I) or research nurse (SET). A video-assisted booster session will be provided 1-2 weeks postoperatively. The primary outcome measure is acute postoperative pain intensity, averaged over the first 7 postoperative days (POD). Secondary outcome measures include long-term postoperative pain control, changes in quantitative sensory testing variables (eg, temporal summation, conditioned pain modulation), sleep, cognition (eg, attention, memory, processing speed, executive function), mental health, health-related function, physical activity, quality of life and blood biomarkers. Participants will undergo on-site evaluation preoperative (preintervention and postintervention) and 6 months postoperative. Additional remote assessments will take place during POD1-7, 3 and 12 months postoperative. ETHICS AND DISSEMINATION: The Swedish Ethical Review Authority has approved the PROSAP-A trial protocol. Results will be published in international peer-reviewed journals and summaries will be provided to funders and participants of the trial. TRIAL REGISTRATION NUMBER: NCT06145516.

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeCognitive Behavioral TherapyPostoperative PainPreoperative CareSleep Initiation and Maintenance DisordersFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSleepInsomniaPain managementSLEEP MEDICINESURGERY

Identifiers

PMID40738630
PMCPMC12314951

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.