Evidence map›Paper›PMID 40738499›Full record

ArticleJournal of movement disorders2025

Retro-Walking and Cholinergic Network Correlates in Parkinson's Disease.

Alexis Griggs, Giulia Carli, Taylor Brown, Prabesh Kanel, Stiven Roytman, Chatkaew Pongmala, Miriam van Emde Boas, Nicolaas Ida Bohnen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexis GriggsUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Giulia CarliFunctional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Taylor BrownUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Prabesh KanelUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Stiven RoytmanUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Chatkaew PongmalaUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Miriam van Emde BoasUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.
Nicolaas Ida BohnenUniversity of Michigan Department of Radiology, Ann Arbor, MI, USA.

Funding

Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAUER, WILLIAM T. · 2014 to 2019
$10.1M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
Michael J. Fox FoundationNIA NIH HHS R01 AG073100NIH HHS P50 NS091856NIH HHS P50 NS123067NIH HHS R01 AG073100NIH HHS R01 NS070856NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856Parkinson's FoundationRRD VA I01 RX001631
6 · The paper itself

Abstract

objectiveTo investigate the cholinergic underpinnings of forward and retro-walking in patients with Parkinson's disease (PwP) using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) positron emission tomography (PET), which binds to the vesicular acetylcholine transporter.

methodsWe retrospectively included 44 PwP who underwent [18F]FEOBV PET imaging and forward- and retro-walking gait assessments. Voxelwise correlation analyses were performed to examine associations between gait velocities and [18F]FEOBV binding, controlling for levodopa equivalent dose and disease duration. Linear regression and mediation analyses were used to investigate the contribution of postural instability and gait disorder symptoms-measured using MDS-UPDRS items and the Mini-Balance Evaluation Systems Test (MiniBESTest)-as well as cognitive performance (attention, memory, executive, language, and visuospatial domains) to the observed associations.

resultsSlower retro-walking velocity was associated with lower [18F]FEOBV uptake in a subcortical-frontal-temporal cluster, including the bilateral middle frontal cortex, anterior cingulate, insula, basal forebrain, and striatal regions. No significant associations were found for forward walking time. Linear regression analyses revealed that MiniBESTest total score, reactive postural control subscore, and attention domain score were associated with both cholinergic uptake in the identified cluster and retro-walking velocities. Mediation analyses revealed that attention and reactive postural control mediated the relationship between [18F]FEOBV binding and retro-walking performance.

conclusionOur findings indicate that retro-walking places greater demands on brain cholinergic synaptic integrity involving subcortical-frontal and temporal cortical regions, subserving balance-particularly reactive postural control-and attentional resources compared to forward walking. Our results suggest that retro-walking might serve as part of an intervention strategy to improve balance and cognition in PwP.

Indexed as

AcetylcholineCognitionGaitParkinson’s diseaseWalking

Identifiers

PMID40738499
PMCPMC12580738

What OpenQuestion holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.