ArticleJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2025
Ophthalmic outcomes five years after lensectomy among children with Down syndrome.
Article in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report demographics and post-lensectomy outcomes in 30 children (39 eyes) with Down syndrome and cataract. Mean age at first lensectomy was 3.0 years (range, 0.04-12.9); 16 of 30 patients (53%) had lensectomy before 12 months of age. The 5-year cumulative incidence of glaucoma-related adverse events was 38% (95% CI, 0%-69%); of retinal detachment, 3% (95% CI, 0%-9%). The median myopic shift in children with refractive data at 5 years was -10.00 D (IQR, -12.50 to -8.38 D) in 11 aphakic eyes and -1.50 D (IQR, -3.00 D to -0.25 D) in 7 pseudophakic eyes. The period prevalence (combining cases at baseline with those developing the condition during follow up) of strabismus by 5 years was 81% (95% CI, 40%-94%), and of nystagmus, 68% (95% CI, 41%-83%). In 11 children able to perform optotype testing, 2 of 12 study eyes (17% [95% CI, 3%-56%]) had visual acuity of 20/60 or better at 5 years.
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