Evidence map›Paper›PMID 40738418›Full record

ArticleBiological psychiatry2026

Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.

Rachel Chudoba, Joanna Dabrowska

Abstract read
In one paragraph

Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Hormonal mechanisms of women's risk in the face of traumatic stress.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachel ChudobaCenter for Neurobiology of Stress Resilience and Psychiatric Disorders, Discipline of Cellular and Molecular Pharmacology, School of Graduate and Postdoctoral Studies, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
Joanna DabrowskaCenter for Neurobiology of Stress Resilience and Psychiatric Disorders, Discipline of Cellular and Molecular Pharmacology, School of Graduate and Postdoctoral Studies, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois. Electronic address: joanna.dabrowska@rosalindfranklin.edu.

Funding

The Integrated Role of Vasopressin and Oxytocin Receptors in the Modulation of BNST Activity and Fear ProcessingR01MH113007 · NIMH · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI Joanna Dabrowska · 2017 to 2026
$4.4M
The role of oxytocin in modulating activity of the supramammillary nucleus and social recognition memoryR01MH138515 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joanna Dabrowska, Xiaoting Wu · 2025 to 2026
$1.5M
NIMH NIH HHS R01 MH113007NIMH NIH HHS R01 MH138515
6 · The paper itself

Abstract

backgroundThe prevalence of posttraumatic stress disorder (PTSD) and anxiety disorders is higher in women than men. The severity of hallmark symptoms including hypervigilance and fear reactivity to unpredictable threats varies with sex and reproductive cycle, but the underlying mechanisms remain unclear. Here, we investigated corticotropin-releasing factor (CRF) neurons in the dorsolateral bed nucleus of the stria terminalis (BNST

methodsA total of 125 male and 156 cycle-monitored female CRF-Cre rats were used. BNST

resultsBNST

conclusionsUnpredictable fear conditioning elicits sex- and estrous phase-specific APS, differentially regulated by BNST

Indexed as

AnxietyCorticotropin-Releasing HormoneEstrous CycleNeuronsReflex, StartleSeptal NucleiAnimalsFearFemaleMaleRatsRats, TransgenicCorticotropin-Releasing HormoneBNSTCRFCRHElectrophysiologyPTSDUnpredictable fear conditioning

Identifiers

PMID40738418
PMCPMC12442882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.