Evidence map›Paper›PMID 40738393›Full record

ArticleActa biomaterialia2025

In Vitro and In Vivo biocompatibility study of fluorinated polyphosphazene coatings for blood-contacting medical devices.

Bryan M Gregorits, Yi Wu, Chen Chen, Eric Yeager, Myddelton C Parker, Isabel Martinez, Meghan L Lancaster, Chad Schmiedt, Hitesh Handa, Harry R Allcock and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bryan M GregoritsDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States; Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Yi WuSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Chen ChenDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
Eric YeagerDepartment of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Myddelton C ParkerSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Isabel MartinezSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Meghan L LancasterDepartment of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States.
Chad SchmiedtDepartment of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States.
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Harry R AllcockDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
Christopher A SiedleckiDepartment of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States; Department of Biomedical Engineering, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Li-Chong XuDepartment of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States. Electronic address: lxx5@psu.edu.

Funding

Combinatorial Approaches to Improved Blood-contacting Polymer BiomaterialsR01HL153231 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SIEDLECKI, CHRISTOPHER A · 2020 to 2023
$2.6M
NanoWizard Ultra Speed 2 High-Speed Atomic Force Microscope for Biomedical ResearchS10OD030279 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SIEDLECKI, CHRISTOPHER A · 2023 to 2023
$600k
NHLBI NIH HHS R01 HL153231NIH HHS S10 OD030279
6 · The paper itself

Abstract

Implant-induced thromboembolic events are the most common complication of blood contacting medical devices. Coatings are a promising approach to improve the biocompatibility of current biomaterials and devices. Poly[bis(trifluoroethoxy) phosphazene] (TFE) has been demonstrated to be biocompatible, anti-inflammatory, and antithrombogenic as a device coating over the past decades; however, its inherently poor mechanical properties make applications in medical devices challenging, especially regarding potential detachment from devices. Our previous work developed a new fluorinated polyphosphazene, poly[bis(octafluoropentoxy) phosphazene] (OFP), and incorporated allylphenoxy side groups to the P-N backbone to make the polymer crosslinkable (X-OFP). In this study, we applied this X-OFP coating on central venous catheters and investigated the surface properties and biocompatibility of the coatings. In vitro and in vivo studies demonstrated that X-OFP has a similar antithrombogenic performance as TFE, but its mechanical properties including adhesion strength of coating-to-substrate are significantly improved, thereby enhancing the stability of the coating. The success of X-OFP will provide a platform to incorporate other side groups to the polymer backbones and generate new fluorinated polyphosphazene polymers having improved biocompatibility and mechanical properties for coating applications in blood-contacting medical devices. STATEMENT OF SIGNIFICANCE: Implant-induced thrombosis is a major complication of blood-contacting medical devices. This study demonstrated a new fluorinated polyphosphazene coating suitable for the medical device with the significant improvement of the biocompatibility of catheters. Compared to the traditional fluorinated polyphosphazene coating, poly[bis(trifluoroethoxy) phosphazene] (TFE), crosslinkable poly[bis(octafluoropentoxy) phosphazene] (X-OFP) contains a higher amount of fluorocarbon content with the octafluoropentoxy side group and is crosslinkable with the allylphenoxy side group. TFE and X-OFP were applied on central venous catheters as coatings. In vitro and in vivo studies demonstrated that X-OFP has a similar antithrombogenic performance as TFE, but its mechanical properties including adhesion strength of coating-to-substrate are significantly improved, thereby enhancing the stability of the coating.

Indexed as

Coated Materials, BiocompatibleHalogenationMaterials TestingOrganophosphorus CompoundsPolymersAnimalsHumansMaleCoated Materials, BiocompatibleOrganophosphorus CompoundsPolymerspoly(phosphazene)BiocompatibilityCatheter coatingFluorinated polyphosphazeneThrombosis

Identifiers

PMID40738393
PMCPMC12379002

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.