Evidence map›Paper›PMID 40738218›Full record

ArticleContemporary clinical trials2025

Research recruitment strategies in the digital era: Opportunities and challenges of social media.

Lauren Uy, Nancy Safwan, Ridwan Ahmad, Erin R Uddenberg, Jana Karam, Maria D Hurtado Andrade, Nicola J Sykes, Stephanie S Faubion, Chrisandra L Shufelt

Abstract read
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren UyDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America.
Nancy SafwanDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America.
Ridwan AhmadDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America.
Erin R UddenbergDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America.
Jana KaramDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America.
Maria D Hurtado AndradeDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Jacksonville, FL, United States of America.
Nicola J SykesMassachusetts Institute of Technology, Cambridge, MA, United States of America.
Stephanie S FaubionDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America; Women's Health Research Center, Mayo Clinic, Rochester, MN, United States of America.
Chrisandra L ShufeltDivision of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States of America; Mayo Clinic Center for Women's Health, Rochester, MN, United States of America; Women's Health Research Center, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Shufelt.chrisandra@mayo.edu.

Funding

Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular HealthR01HD106096 · NICHD · MAYO CLINIC JACKSONVILLE · PI SHUFELT, CHRISANDRA LEE · 2021 to 2024
$3.6M
Genetic and Metabolic Determinants of 25(OH)D levels at Baseline and One Year: Findings from a Dose Ranging Vitamin D trialD43TW009118 · FIC · AMERICAN UNIVERSITY OF BEIRUT · PI FULEIHAN, GHADA ELHAJJ · 2012 to 2024
$2.5M
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young WomenK23HL127262 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHUFELT, CHRISANDRA LEE · 2016 to 2020
$988k
Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
FIC NIH HHS D43 TW009118NHLBI NIH HHS K23 HL127262NIAMS NIH HHS K12 AR084222NICHD NIH HHS R01 HD106096
6 · The paper itself

Abstract

backgroundEffective recruitment is crucial for clinical research, yet traditional methods can be costly and time-consuming. Digital platforms offer a promising opportunity for reaching broader populations. This paper aims to provide a descriptive analysis of digital and traditional recruitment strategies used to engage women with functional hypothalamic amenorrhea (FHA) and identify the most effective methods.

methodsFrom January 2023 to November 2024, women aged 18-40 were recruited through traditional methods (flyers, referrals, word-of-mouth, health fairs) and digital platforms (Instagram, X, Facebook, Reddit, podcasts, electronic boards, clinical trial websites, data exploration tool). Respondents were categorized into "All", "Consented," and "Completed," then stratified by generation and geographic location. Enrollment and completion rates were calculated.

resultsAmong 220 respondents (mean age 28.0 ± 5.9 years), 74 (34 %) consented, and 47 (21 %) completed participation. Of all responses, Instagram provided the highest recruitment (37 %, n = 82), but had the lowest enrollment rate (17 %). Podcasts and word-of-mouth were also effective, with physician referrals yielding the highest enrollment (80 %) and completion (100 %) rates yet representing one of the lowest recruitment counts (n = 5). While digital strategies had three times more outreach, enrollment and completion rates remained similar to those of traditional methods. Millennials (n = 117) relied more on Facebook and Podcasts, while Gen Z (n = 102) engaged more via electronic boards and Reddit.

conclusionsDigital platforms, particularly social media and podcasts showed significant potential to enhance recruitment efficiency and outreach. However, varying completion rates across methods underscore the importance of a multifaceted approach to ensure participant diversity and study generalizability.

Indexed as

Patient SelectionSocial MediaAdolescentAdultFemaleHumansYoung AdultFunctional hypothalamic amenorrheaGeneration ZMillennialRecruitmentResearch studySocial media

Identifiers

PMID40738218
PMCPMC12418363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.