ArticleThe American journal of clinical nutrition2025
Investigating the impact of body weight changes and blood lipids on risk for mild cognitive impairment in Parkinson's disease: a prospective cohort study.
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundParkinson´s disease (PD) is a neurodegenerative disorder with high risk of cognitive impairment and dementia, where a known risk factor pattern includes low body weight and low blood lipids.
objectivesThis cohort study investigates prospective associations between changes in body mass index (BMI), plasma triglycerides (P-TG) and plasma cholesterol with mild cognitive impairment (MCI) at time of PD diagnosis.
methodsPatients with PD were identified prospectively in a community-based study of idiopathic Parkinsonism (n = 151) where the patient database was crosslinked to the Northern Sweden Health and Disease Study. The present prospective cohort study (n = 96) considers the timepoint for the healthcare visit the baseline and time for diagnosis as follow-up. At diagnosis of PD, 42 patients (43.8%) were diagnosed with MCI. Associations between prodromal body weight changes and blood lipids with risk of MCI at PD diagnosis were assessed with logistic regression [odd ratio (OR) and 95% confidence intervals (CIs)] adjusted for age and sex.
resultsHigh P-TG at time of diagnosis were protective for MCI whereas a high age increased risk in patients with PD (OR: 0.31; 95% CI: 0.11, 0.87 and OR: 1.11; 95% CI: 1.02, 1.22, respectively). BMI was not predictive for MCI, neither at diagnosis nor for change over time (adjusted OR 0.99; 95% CI: 0.88, 1.13 and OR 1.12; 95% CI: 0.94, 1.33, respectively). An increase in P-TG was protective for MCI (OR: 0.34; 95% CI: 0.13, 0.88) whereas an interaction between change in BMI and P-TG (OR: 2.21; 95% CI: 1.02, 4.77) increased risk.
conclusionsHigh risk of MCI in patients with PD at the time of diagnosis was associated with low levels of P-TG and an interaction between change in BMI and P-TG before diagnosis, suggesting that nutritional factors have complex influence on cognitive function in the prodromal stage of PD.
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