ArticleImmunity2025
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.
Abstract read
In one paragraph
Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Dysregulated tissue immunity in human fatal asthma.Nature communications · 2026Article
- From data to discovery: a unified framework for human immunology.Nature immunology · 2026Article
- Review
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- The ageing immune system and its battle with viruses.The Journal of general virology · 2026Review
- Dynamic remodeling of the pancreas immune landscape in obesity.Nature communications · 2026Article
- Age dependent collective trafficking of tissue resident T cells in zebrafish.bioRxiv : the preprint server for biology · 2026Article
- Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nature immunology · 2026Article
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme KImmunity · 2026Article
- T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
- Age determines NK cell fate and tissue compartmentalization to CMV infection.bioRxiv : the preprint server for biology · 2026Article
- Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection.Research square · 2026Article
- Development and External Validation of a Nomogram for Predicting Postherpetic Neuralgia Risk in Patients with Herpes Zoster: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Human epidermal resident memory T cells: beyond the dermal perspective.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Nora LamDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
J Carlos AngelDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY 10032, USA; New York Genome Center, New York, NY 10013, USA.
Bruce A BuchholzCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
YoonSeung LeeDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Stuart P WeisbergDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Brea H BrownDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Julia Davis-PoradaDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA.
Daniel P CaronDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Isaac J JensenDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Basak B UralDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Steven B WellsDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Masaru KubotaDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Rei MatsumotoDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Maigan BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Todd M BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Chao LuDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Andrew J YatesDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4MTranscriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1MVASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BROWN, TRUMAN R · 1989 to 2008
$21.7MEpidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1MGenetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9MMedical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3MNational User Resource for Biological Accelerator Mass SpectrometryR24GM137748 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI BENCH, GRAHAM · 2020 to 2024
$6.5MModeling the ecology of tissue-resident T cellsU01AI150680 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L., YATES, ANDREW · 2020 to 2024
$5.0MEvolution of T cell immunity in blood and tissues over childhoodU01AI168634 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2022 to 2026
$4.1MMolecular basis for aberrant de novo DNA methylation in cancerR01CA266978 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Karim Jean Armache, Chao Lu · 2022 to 2026
$2.6MNCI NIH HHS K99 CA212257NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA266978NHLBI NIH HHS U01 HL145547NIAID NIH HHS F30 AI174785NIAID NIH HHS P01 AI106697NIAID NIH HHS T32 AI106711NIAID NIH HHS U01 AI150680NIAID NIH HHS U01 AI168634NIA NIH HHS K00 AG073570NIA NIH HHS K01 AG078439NIA NIH HHS P01 AG007232NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG037212NIA NIH HHS RF1 AG054023NIA NIH HHS U24 AG056270NIGMS NIH HHS R24 GM137748NIGMS NIH HHS R35 GM138181NIGMS NIH HHS T32 GM145440NIH HHS S10 OD020056NIH HHS S10 OD030282
Abstract
Memory T cells are maintained in tissues as circulating effector-memory (T
Indexed as
AgingImmunologic MemoryMemory T CellsT-Lymphocyte SubsetsAdultAgedAged, 80 and overCellular SenescenceDNA MethylationEpigenesis, GeneticFemaleHumansImmunosenescenceMaleMiddle AgedTranscriptomeagingepigeneticshistologyimmunosenescencemucosal immunityT cellstissue-resident memory T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.