Evidence map›Paper›PMID 40738024›Full record

ArticleActa haematologica2026

Increased Prevalence of Thromboembolic Events in Patients with Congenital Dyserythropoietic Anemia Type I.

Mahdi Asleh, Aya Khalaila, Yotam Eshel, Kayed Al-Athamen, Joseph Kapelushnik, Hagit Miskin

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Article in Acta haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mahdi AslehPediatric Hemato-Oncology Department, Saban Pediatric Medical Center, Soroka University Medical Center, Beer-Sheva, Israel, dr.asleh@gmail.com.
Aya KhalailaPediatric Hemato-Oncology Department, Saban Pediatric Medical Center, Soroka University Medical Center, Beer-Sheva, Israel.
Yotam EshelPediatric Hemato-Oncology Department, Saban Pediatric Medical Center, Soroka University Medical Center, Beer-Sheva, Israel.
Kayed Al-AthamenFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Joseph KapelushnikPediatric Hemato-Oncology Department, Saban Pediatric Medical Center, Soroka University Medical Center, Beer-Sheva, Israel.
Hagit MiskinPediatric Hemato-Oncology Department, Saban Pediatric Medical Center, Soroka University Medical Center, Beer-Sheva, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Congenital dyserythropoietic anemia type I (CDA-I) is a rare disorder of erythropoiesis. All CDA-I patients are expected to have iron overload and chronic hemolysis. Patients with severe anemia may undergo splenectomy. Hemochromatosis, chronic hemolysis, and splenectomy are all found to increase risk for thromboembolism in thalassemic patients. As CDA-I patients have similar findings, we sought to evaluate prevalence of thromboembolic events (TEEs) in these patients.

methodsA retrospective case-control study was conducted, including 110 CDA-I patients (study group) and 326 age- and sex-matched iron deficiency anemia patients of the same ethnicity (control group). Patients were risk-stratified using Risk Assessment Models for thromboembolism.

resultsWe identified 3 cases (2.7%) with TEEs in the CDA group and 1 case (0.3%) in the control group. All patients were females. VTE risk scores were low to moderate for CDA patients and higher for IDA patient. When compared to control group, CDA-I patients were nine times more likely to develop TEE (OR 9.11, 95% CI = 1.15-185.27, p = 0.057). All 3 CDA patients had a history of remarkable hemolysis and iron overload. Two underwent splenectomy.

conclusionThese findings show that CDA patients appear to be at increased risk for TEEs. </p>.

Indexed as

Anemia, Dyserythropoietic, CongenitalHemolysisIron OverloadThromboembolismAdolescentAdultCase-Control StudiesChildFemaleHumansMalePrevalenceRetrospective StudiesRisk FactorsYoung AdultCongenital dyserythropoietic anemiaDeep vein thrombosisHemochromatosisIron overloadThromboembolism

Identifiers

PMID40738024
PMCPMC12503651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.