ArticleScience advances2025
Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Fast 3-D Ultrasound Localization Microscopy via Projection-Based Processing Framework.IEEE transactions on medical imaging · 2026Article
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- Hydrogel metapad with ultrasound transparency and broadband focusing for biomedical imaging.National science review · 2026Article
- Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system.Theranostics · 2025Article
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Authors and funding
6 authors.
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Abstract
Transcranial ultrasound imaging is usually limited by skull-induced attenuation and high-order aberrations. By using contrast agents such as microbubbles in combination with ultrafast imaging, not only can the signal-to-noise ratio be improved, but super-resolution images down to the micrometer scale of the brain vessels can also be obtained. However, ultrasound localization microscopy (ULM) remains affected by wavefront distortions that limit the microbubble detection rate and hamper their localization. In this work, we show how ultrasound matrix imaging, which relies on the prior recording of the reflection matrix, can provide a solution to these fundamental issues. As an experimental proof of concept, an in vivo reconstruction of deep brain microvessels is performed on three anesthetized sheep. The compensation of wave distortions is shown to markedly enhance the contrast and resolution of ULM. This experimental study thus opens up promising perspectives for a transcranial and nonionizing observation of human cerebral microvascular pathologies, such as stroke.
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