Evidence map›Paper›PMID 40737327›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Evolution and evolvability of rifampicin resistance across the bacterial tree of life.

Negin Bolourchi, Christopher R P Brown, Andrew D Letten, Jan Engelstädter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Pyocyanin produced byAntimicrobial agents and chemotherapy · 2026
    Article
  2. Review
  3. "Excluded phenotypes" restrict genetic paths toward adaptation in declining populations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Negin BolourchiSchool of the Environment, The University of Queensland, Brisbane, QLD 4072, Australia.
Christopher R P BrownSchool of the Environment, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-0393-3477
Andrew D LettenSchool of the Environment, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-6436-7942
Jan EngelstädterSchool of the Environment, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-3340-918X

Funding

Department of Education and Training | Australian Research Council (ARC) DP190102485
6 · The paper itself

Abstract

Predicting the ability of bacteria to develop antibiotic resistance is challenging, especially for the vast majority of species for which no experimental data are available. Here, we investigated the evolvability and intrinsic presence of rifampicin resistance across the bacterial tree of life. We compiled a comprehensive panel of known rifampicin resistance mutations, comprising 57 amino acid substitutions within the gene

Indexed as

BacteriaDrug Resistance, BacterialEvolution, MolecularRifampinBacterial ProteinsDNA-Directed RNA PolymerasesGenome, BacterialMutationPhylogenyBacterial ProteinsDNA-Directed RNA PolymerasesRifampinantibiotic resistanceevolvabilityintrinsic resistancemutational spectrumrifampicin

Identifiers

PMID40737327
PMCPMC12337354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.