Evidence map›Paper›PMID 40737323›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Trauma-predictive brain network connectivity adaptively responds to mild acute stress.

Felicia A Hardi, Jean Ye, Irene Zhou, Zihan Bai, D T Nguyen, Krystian B Loetscher, Julia G Pratt, Bailey B Harris, Dylan G Gee, Elizabeth V Goldfarb

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Felicia A HardiWu Tsai Institute, Yale University, New Haven, CT 06510.ORCID 0000-0002-3975-9159
Jean YeInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511.
Irene ZhouDepartment of Psychology, Yale University, New Haven, CT 06510.ORCID 0009-0008-9739-2317
Zihan BaiDepartment of Psychiatry, Yale University, New Haven, CT 06511.
D T NguyenDepartment of Psychology, University of Virginia, Charlottesville, VA 22903.
Krystian B LoetscherInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511.ORCID 0000-0002-2083-4294
Julia G PrattDepartment of Psychiatry, Yale University, New Haven, CT 06511.
Bailey B HarrisDepartment of Psychology, University of California, Los Angeles, CA 90095.
Dylan G GeeWu Tsai Institute, Yale University, New Haven, CT 06510.ORCID 0000-0002-3685-2710
Elizabeth V GoldfarbWu Tsai Institute, Yale University, New Haven, CT 06510.ORCID 0000-0001-9869-7771

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Neuroimaging multiple memory processes, glucocorticoids and alcoholism riskK01AA027832 · NIAAA · YALE UNIVERSITY · PI GOLDFARB, ELIZABETH · 2020 to 2024
$879k
Neural mechanisms of stress effects across hippocampal encoding and predictionR21MH128740 · NIMH · YALE UNIVERSITY · PI GOLDFARB, ELIZABETH · 2022 to 2023
$461k
Brain and Behavior Research Foundation (BBRF) Young Investigator AwardHHS | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR001862HHS | NIH | National Institute of Mental Health (NIMH) R21MH128740HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) K01AA027832NCATS NIH HHS KL2 TR001862NIAAA NIH HHS K01 AA027832NIMH NIH HHS R21 MH128740VA | National Center for PTSD, U.S. Department of Veterans Affairs (NCPTSD) N/AWu Tsai Institute Postdoctoral Fellowship N/A
6 · The paper itself

Abstract

Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we assessed how trauma-related brain networks respond to current acute stress in real time. Using a machine learning approach, we trained and tested brain functional connectivity networks to predict past trauma exposure in a community sample of adults (

Indexed as

BrainNerve NetStress, PsychologicalAdultConnectomeCross-Over StudiesFemaleHumansHydrocortisoneMachine LearningMagnetic Resonance ImagingMaleMiddle AgedYoung AdultHydrocortisoneacute stressdepressionpredictive brain networkstrauma

Identifiers

PMID40737323
PMCPMC12327799

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.