ArticlePLoS neglected tropical diseases2025
LeishTec vaccination disrupts vertical transmission of Leishmania infantum.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intracellular Parasitic Infections Caused byVaccines · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Zoonotic canine leishmaniosis, caused by Leishmania infantum, is a fatal disease worldwide in both humans and the reservoir host, dogs. The primary route of transmission is via sand fly bite. Vertical, transplacental, transmission of L. infantum to offspring has been shown to be critical for maintenance of infection in both endemic and non-endemic areas. In the United States, canine leishmaniosis (CanL) is enzootic within hunting dog populations. Previous work with US hunting dogs found that transplacental transmission of L. infantum occurs frequently with high infectivity. Dogs born to CanL infected mothers were almost fourteen times more likely to become positive for L. infantum over their lifetime. Globally, public health agencies control CanL through canine and human case detection and treatment, and in some cases dog culling and reducing vector populations. There is no specific strategy to control vertical transmission of CanL. A previous randomized field trial in US hunting dogs found that a Leishmania A2 protein, saponin-adjuvanted, vaccine (LeishTec) used as an immunotherapy, significantly reduced the risk of progression to clinically overt leishmaniasis by 30% in asymptomatic dogs. It is unknown whether maternal vaccination could inhibit infection risk in her offspring. We hypothesized that dogs born to infected and vaccinated dams would be less likely to test diagnostically positive via L. infantum specific kqPCR or serology compared to dogs born to infected unvaccinated mothers. A population of dogs born to L. infantum infected dams were evaluated to assess LeishTec vaccination to prevent transmission to offspring. Dogs born to unvaccinated, L. infantum infected, dams had higher mortality (12.50% vs 0.00%), higher likelihood of clinical disease (94.12% vs 59.00%) and were more likely to be diagnostically positive for CanL (22.22% vs 4.55%). Vaccination of dams already infected prior to pregnancy greatly reduced the risk of transplacental transmission of L. infantum. Incorporating vertical transmission prevention as a public health intervention in countries where Leishmania is endemic could aid in infection control.
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Registered trials
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